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Nmda Receptor Blockade Unmasks Novel Gating and Memory Mechanisms in Vagal Control of Respiratory Rhythm

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Frontiers in Modeling and Control of Breathing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 499))

Abstract

Afferent feedback from lung receptors plays a key role in the vagal self-steering control of the respiratory rhythm.1,2 Although this control process is generally considered to be purely reflexive, there is increasing recognition that the central processing of these afferent inputs may involve more complex mechanisms such as memory and gating in the respiratory controller.3 For example, it was recently shown4 that the Hering-Breuer reflex may be adapted centrally through dual-process nonassociative learning in the form of habituation and desensitization in parallel vagal-pontine pathways to the respiratory central pattern generator (RCPG).

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Young, D.L., Siniaia, M.S., Poon, CS. (2001). Nmda Receptor Blockade Unmasks Novel Gating and Memory Mechanisms in Vagal Control of Respiratory Rhythm. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_41

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  • DOI: https://doi.org/10.1007/978-1-4615-1375-9_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5522-9

  • Online ISBN: 978-1-4615-1375-9

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