Neurogenesis of the Respiratory Pattern: Insights from Computational Modeling
The primary respiratory rhythm generator is located in a relatively small area of the lower brainstem and can be defined by the neuronal properties and synaptic interactions within this limited area. The genesis and control of the respiratory motor pattern involve a complex cross-level integration of cellular, network and systems mechanisms. Computational modeling is a powerful method that allows linking experimental data related to different levels of system organization. Therefore, a comprehensive computational model can provide useful insights for understanding the multilevel neural mechanisms involved in generation and control of the respiratory pattern. Our ultimate goal is to develop such a model.
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- 1.D. W. Richter, in: Comprehensive Human Physiology, edited by R. Gregor and U. Windhorst (Springer-Verlag, Berlin, 1996, vol. II), pp. 2079–2095.Google Scholar
- 2.D. Richter, D. Ballantyne, and J. E. Remmers, How is the respiratory rhythm generated? A model, News Physiol. Sci. 1, 109–112 (1986).Google Scholar
- 4.M. I. Cohen and J. L. Feldman, Models of respiratory phase-switching, Federation Proc. 36, 2367–2374 (1977).Google Scholar
- J. L. Feldman, in: Handbook of Physiology, edited by F. E. Bloom (Am. Physiol. Soc., Bethesda, MD, 1986, sec. 1, vol. 4), pp. 463–524.Google Scholar
- 6.S. Klages, M. C. Bellingham, and D. W. Richter, Late expiratory inhibition of stage 2 expiratory neurons in the cat - A correlate of expiratory termination, J. Physiol. Lond. 70, 1307–1315 (1993).Google Scholar
- 7.C. von Euler, in: Handbook of Physiology. The Respiratory System II, edited by N. S. Cherniack and J. G. Widdicombe (Am. Physiol. Soc., Washington, DC, 1986), pp. 1–67.Google Scholar
- 9.F. J. Clark and C. von Euler, On the regulation of depth and rate of breathing, J. Physiol. Lond. 222 267295 (1972).Google Scholar
- J. E. Remmers, D. W. Richter,.D. BallantyneGoogle Scholar