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Respiratory Rhythm Generation: Prebötzinger Neuron Discharge Patterns and Persistent Sodium Current

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Frontiers in Modeling and Control of Breathing

Abstract

Neurons within the preBötzinger complex (pBc) are postulated to have a central role in respiratory rhythm generation. This postulate is supported by studies using both in vitro and in vivo preparations.2 Consistent with a role in rhythm generation, many of the neurons within this region discharge with active periods that span the phase transitions between expiration (E) and inspiration (I),3, 4

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McCrimmon, D.R., Monnier, A., Ptak, K., Zummo, G., Zhang, Z., Alheid, G.F. (2001). Respiratory Rhythm Generation: Prebötzinger Neuron Discharge Patterns and Persistent Sodium Current. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_23

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  • DOI: https://doi.org/10.1007/978-1-4615-1375-9_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5522-9

  • Online ISBN: 978-1-4615-1375-9

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