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Interfacing Computer Models with Real Neurons: Respiratory “Cyberneurons” Created with the Dynamic Clamp

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Frontiers in Modeling and Control of Breathing

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 499))

Abstract

The mechanism of respiratory rhythm generation remains an important unsolved problem. While experimental evidence has been collected about the location and distribution of respiratory neurons within the mammalian brainstem, only recently has the locus of rhythm generating neurons been discovered, 1 a functionally identified region of the brainstem known as the pre-Bötzinger complex (pre-BötC). We have just begun to investigate the membrane and network properties of pre-BötC neurons underlying the generation and transmission of inspiratory rhythm.2,3,4,5

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References

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Author information

Authors and Affiliations

  1. Cellular and Systems Neurobiology Section, NINDS, NIH, Bethesda, Maryland, 20892, USA

    Christopher G. Wilson, Christopher A. Del Negro & Jeffrey C. Smith

  2. Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, 30332, USA

    Robert J. Butera Jr.

  3. Center for Neural Science and Courant Institute of Mathematical Science, New York University, New York, 10013, USA

    John Rinzel

Authors
  1. Christopher G. Wilson
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  2. Robert J. Butera Jr.
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  3. Christopher A. Del Negro
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  4. John Rinzel
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  5. Jeffrey C. Smith
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Editor information

Editors and Affiliations

  1. Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    Chi-Sang Poon

  2. Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Homayoun Kazemi

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© 2001 Springer Science+Business Media New York

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Wilson, C.G., Butera, R.J., Del Negro, C.A., Rinzel, J., Smith, J.C. (2001). Interfacing Computer Models with Real Neurons: Respiratory “Cyberneurons” Created with the Dynamic Clamp. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_19

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  • DOI: https://doi.org/10.1007/978-1-4615-1375-9_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5522-9

  • Online ISBN: 978-1-4615-1375-9

  • eBook Packages: Springer Book Archive

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