Abstract
Hypoglossal motoneurons innervate the tongue muscles1which participate in a variety of motor tasks, including breathing.2Understanding the respiratory control of hypoglossal motoneurons is essential because of their critical involvement in maintaining airway patency during normal breathing, and their putative role in the pathogenesis of obstructive sleep apnea.3, 4Despite such importance in both normal and altered physiological states, virtually nothing is known about how respiratory rhythm is transmitted to them.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. G. Dobbins, and J. L. Feldman, Differential innervation of protruder and retractor muscles of the tongue in ratJ. Comp. Neurol. 357376–394 (1995).
A. A. Lowe, The neural regulation of tongue movementsProg. Neurobiol. 15, 295–344 (1981).
J. E. Remmers, W. J. de Groot, E. K. Sauerland, and A. M. Anch, Pathogenesis of upper airway occlusion during sleepJ. Appl. Physiol. 44, 931–938 (1978).
R. F. Fregosi, and D. D. Fuller, Respiratory-related control of extrinsic tongue muscle activityRespir. Physiol. 110295–306 (1997).
R. C. Borke, E. Martin, and R. L. Ringler Jr., Brain stem afferents of hypoglossal neurons in the ratBrain Res. 26947–55 (1983).
G. Ugolini, Specificity of rabies virus as a transneuronal tracer of motor networks: Transfer from hypoglossalmotoneurons to connected second-order and higher order central nervous system cells groupsJ. Comp. Neurol. 356457–480 (1995).
Y.-Q. Li, M. Takada, and N. Mizuno, Identification of premotor interneurons which project bilaterally to the trigeminal motor, facial or hypoglossal nuclei: A fluorescent retrograde double-labeling study in the ratBrain Res. 611160–164 (1993).
Y. Sahara, N. Hashimoto, and Y. Nakamura, Hypoglossal premotor neurons in the rostral medullary parvocellular reticular formation participate in cortically-induced rhythmical tongue movementsNeurosci. Res. 26, 119–131 (1996).
G. Holstege, H. G. J. M. Kuypers, and J. J. Dekker, The organization of the bublar fibre connections to the hypoglossal motor nucleiBrain 100, 256–286 (1977).
M. Takada, K. Itoh, Y. Yasui, A. Mitani, S. Nomura, and N. Mizuno, Distribution of premotor neurons for the hypoglossal nucleus in the catNeurosci. Lett. 52, 141–146 (1984).
T. Ono, Y. Ishiwata, N. Inaba, T. Kuroda, and Y. Nakamura, Hypoglossal premotor neurons with rhythmical inspiratory-related activity in the cat: Localization and projection to the phrenic nucleusExp. Brain Res. 981–12 (1994).
T. Ono, Y. Ishiwata, N. Inaba, T. Kuroda, and Y. Nakamura, Modulation of the inspiratory-related activity of hypoglossal premotor neurons during ingestion and rejection in the decerebrate catJ. Neurophysiol. 80, 48–58 (1998).
G. F. Tian, and J. Duffin, Connections from upper cervical inspiratory neurons to phrenic and intercostal motoneurons studied with cross-correlation in the decerebrate ratExp. Brain Res. 110196–204 (1996).
T. A. Sears, and D. Stagg, Short-term synchronization of intercostal motoneurone activityJ. Physiol. 263357–381 (1976).
K. Graham, and J. Duffin, Cross correlation of medullary expiratory neurons in the catExptl. Neurol. 73, 451–464 (1981).
M. A. Douse, J. Duffin, D. Brooks, and L. Fedorko, Role of upper cervical inspiratory neurons studied by cross-correlation in the catExp. Brain Res. 90153–162 (1992).
G. F. Tian, J. H. Peever, and J. Duffin, Bötzinger-complex expiratory neurons monosynaptically inhibit phrenic motoneurons in the decerebrate ratExp. Brain Res. 122, 149–156 (1998).
J. D. Green, and K. Negishi, Membrane potentials in hypoglossal motoneuronsJ. Neurophysiol. 26, 835–856 (1963).
T. Sumi, Functional differentiation of hypoglossal neurons in catsJpn. J. Physiol. 1955–67 (1969).
G. Woch, and L. Kubin, Non-reciprocal control of rhythmic activity in respiratory-modulated XII motoneuronsNeuroReport 6, 2085–2088 (1995).
D. J. Withington-Wray, S. W. Mifflin, and K. M. Spyer, Intracellular analysis of respiratory-modulated hypoglossal motoneurons in the catNeuroscience 25, 1041–1051 (1988).
G. F. Tian, J. H. Peever, and J. Duffin, Bötzinger-complex, bulbospinal expiratory neurons monosynaptically inhibit ventral-group respiratory neurons in the decerebrate ratExp. Brain Res. 124173–180 (1999).
T. B. Boone, and L. D. Aides, The ultrastructure of two distinct neuron populations in the hypoglossal nucleus of the ratExp. Brain Res. 54321–326 (1984).
N. Takasu, and P. H. Hashimoto, Morphological identification of an interneuron in the hypoglossal nucleus of the rat: A combined golgi-electron microscopic studyJ. Comp. Neurol. 271461–471 (1988).
M. N. Cooper, The hypoglossal nucleus of the primate: A golgi studyNeurosci. Lett. 21, 249–254 (1981).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Peever, J.H., Duffin, J. (2001). Respiratory Control of Hypoglossal Motoneurons. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1375-9_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5522-9
Online ISBN: 978-1-4615-1375-9
eBook Packages: Springer Book Archive