Abstract
α2-adrenoceptors (α2-ARs) are widely distributed in the CNS including brainstem sites associated with cardiorespiratory control. 1,2 Several lines of evidence strongly suggest a role for α2-ARs in the regulation of respiratory rhythm. We have recently demonstrated that systemic administration of clonidine and other α2-AR agonists cause profound disturbances in respiratory pattern in the goat that are characterized by alternating episodes of tachypnea and respiratory depression (prolonged and variable expiratory time intervals).3-8 Dysrhythmic breathing induced by α2-AR agonists in the goat is associated with continuous tonic activation of expiratory-related drive in laryngeal4,5 and pharyngeal motoneurons6,8 leading to active airway closure during central apnea.6,8
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O’Halloran, K.D., Herman, J.K., Bisgard, G.E. (2001). Activation of Medullary Post-Inspiratory Related Neurons During Clonidine-Induced Central Apnea in Anesthetized Goats. In: Poon, CS., Kazemi, H. (eds) Frontiers in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 499. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1375-9_15
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DOI: https://doi.org/10.1007/978-1-4615-1375-9_15
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