The Transforming Growth Factors Beta in Development and Functional Differentiation of the Mouse Mammary Gland
The transforming growth factors beta (TGF-ß) are multifunctional regulators with diverse effects on a variety of developmental processes and differentiated functions. In the mammary gland, a considerable amount of evidence has accumulated indicating that TGF- 3 plays a critical role during several phases of the mammary cycle. TGF-(3 regulates growth and patterning of the mammary ductal tree in the virgin mouse. During pregnancy, TGF-ß is required for alveolar development and functional differentiation, while at the same time inhibiting secretion of milk proteins. At parturition this inhibition is lifted, permitting initiation of lactation.
KeywordsMammary Gland Functional Differentiation Mouse Mammary Tumor Virus Mouse Mammary Gland Alveolar Development
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