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Detection of Four Human Milk Groups with Respect to Lewis-Bloodgroup-Dependent Oligosaccharides by Serologic and Chromatographic Analysis

  • B. Stahl
  • S. Thurl
  • J. Henker
  • M. Siegel
  • B. Finke
  • G. Sawatzki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 501)

Abstract

Oligosaccharides from human milk samples obtained from individual donors were analyzed using high-pH anion-exchange chromatography. Three patterns of neutral oligosaccharides were detected corresponding to milk groups already described. These oligosaccharide groups correspond to the Lewis blood types Lea-b+Lea+b-and Lea-b-. A new carbohydrate pattern was detected in a milk sample from a Lea-b-person in which only nonfucosylated oligosaccharides and compounds bearing al,3-linked fucosyl residues were found. This finding led to the hypothesis that there exist 4 different oligosaccharide milk groups that fit well to the genetic basis of the Lewis blood group system.

Keywords

Milk Sample Human Milk Fucose Residue Milk Oligosaccharide Human Milk Sample 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • B. Stahl
    • 1
  • S. Thurl
    • 2
  • J. Henker
    • 3
  • M. Siegel
    • 4
  • B. Finke
    • 1
  • G. Sawatzki
    • 5
  1. 1.Numico Research Germany FriedrichsdorfGermany
  2. 2.Faculty of Food TechnologyUniversity of Applied SciencesFuldaGermany
  3. 3.Carl Gustav Carus Medical CenterTechnical University of DresdenDresdenGermany
  4. 4.Red Cross Blood Donor CenterInstitute of Transfusion Medicine DresdenGermany
  5. 5.SciNuTec GmbH MünzenbergGermany

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