Structural and Functional Aspects of Three Major Glycoproteins of the Human Milk Fat Globule Membrane

  • Jerry A. Peterson
  • Ciaran D. Scallan
  • Roberto L. Ceriani
  • Margit Hamosh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 501)


The MUC1 mucin, lactadherin, and butyrophilin are 3 major components of the human milk fat globule membrane. The mucin inhibits binding of S-fimbriatedEscherichia callto buccal epithelial cells, and lactadherin prevents symptomatic rotavirus infection in breast-fed infants. Butyrophilin has been suggested to be a structural component of the human milk fat globule (HMFG) membrane and to have receptor functions, but has no known anti-infective activity. These HMFG glycoproteins also are present in skimmed milk, possibly associated with phospholipid micelles, while mucin is also in a soluble form. Mucin and lactadherin resist digestion in the stomach of milk-fed infants, while butyrophilin is rapidly degraded. The MUC1 mucin is an extended rod-like structure forming part of the glycocalyx on the surface of many epithelial cells and membranes of milk, and may act as a decoy for binding of infective agents. The extracellular segment of butyrophilin has homology to Ig superfamily receptors and an intracellular domain with homology to developmentally regulated proteins. Lactadherin is a laterally mobile cell adhesion molecule that interacts with integrins and has a novel means of membrane-association involving specific binding to phosphatidylserine. The structural and functional aspects of these glyco-proteins are discussed with regard to their role in human milk for breast-fed infants.


Human Milk Major Histocompatability Complex Buccal Epithelial Cell MUCI Mucin Major Histocompatability Complex Class 
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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Jerry A. Peterson
    • 1
  • Ciaran D. Scallan
    • 1
  • Roberto L. Ceriani
    • 1
  • Margit Hamosh
    • 2
  1. 1.Cancer Research Institute of Contra CostaSan FranciscoCA
  2. 2.Department of PediatricsGeorgetown University Medical CenterWashington

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