Chronic Administration of Phenyl N-TERT- Butylnitrone Protects the Retina Against Light Damage
Retinal dystrophies comprise a large number of disorders characterized by a slow and progressive retinal degeneration. Most are the results of mutations expressed in either photoreceptor or retinal pigment epithelial cells. There is currently no treatment by which the primary disorder can be modified, although researchers around the world are working on different potential therapeutic approaches to treat retinal degenerations. These are based on the possibility of transfecting the photoreceptor or retinal epithelial cells with a functioning gene, transplanting photoreceptor or retinal pigment epithelial cells into the sub-retinal space, using electronic devices to stimulate the retina, or administrating drugs to enhance the repair/defense systems of the retina. Although encouraging success has been shown in animals models, gene therapy1, transplantation2 or injection of growth factors3,4,5 require invasive intraocular procedures and some have significant side effects.
KeywordsOptic Nerve Retinal Pigment Epithelial Cell Retinal Degeneration Outer Nuclear Layer Osmotic Pump
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- 8.D.T. Organisciak, R.M. Darrow, I.R. Bicknell, Y.L. Jiang, M. Pickford, J.C. Blanks,Protection against retinal light damage by natural and synthetic antioxidants. In: Retinal Degenerations, edited by R.E. Anderson, J.G. Hollyfield, M.M. LaVail (Plenum Press, New York and London, 1991), pp. 189–201.Google Scholar
- 11.I. Ranchon, J. White, S. Chen, K. Alvarez, R.E. Anderson, Systemic Administration of Phenyl-N-tert-butylnitrone Protects the Retina from Light Damage. Submitted to Invest. Ophthalmol. Vis. Sci. (2000)Google Scholar
- 16.L.M. Rapp, M.I. Naasn, R.D. Wiegand, et al. Morphological and biochemical comparison between retinal regions having differing susceptibility to photoreceptor degeneration. In: Retinal Degeneration: Experimental and Clinical Studies, edited by M.M. La Vail, J.G. Hollyfield, R.E. Anderson (New York: Alan RLiss, 1985) pp. 421–437.Google Scholar
- 20.L. Feeney, E.R. Berman, Oxygen toxicity: membrane damage by free radicals. Invest. Ophthalmol. Vis. Sci. 15, 789–792 (1976).Google Scholar