Abstract
Retinal dystrophies comprise a large number of disorders characterized by a slow and progressive retinal degeneration. Most are the results of mutations expressed in either photoreceptor or retinal pigment epithelial cells. There is currently no treatment by which the primary disorder can be modified, although researchers around the world are working on different potential therapeutic approaches to treat retinal degenerations. These are based on the possibility of transfecting the photoreceptor or retinal epithelial cells with a functioning gene, transplanting photoreceptor or retinal pigment epithelial cells into the sub-retinal space, using electronic devices to stimulate the retina, or administrating drugs to enhance the repair/defense systems of the retina. Although encouraging success has been shown in animals models, gene therapy1, transplantation2 or injection of growth factors3,4,5 require invasive intraocular procedures and some have significant side effects.
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References
M. Cayouette, D. Behn, M. Sedtner, P. Lachapelle, C. Gravel, Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse, J. Neurosci. 18,9282–9293 (1998).
F. Ghosh, B. Ehinger, Full-thickness retinal transplants: a review. Ophthalmologica 214,54–69 (2000)
M.M. LaVail, D. Yasumura, M.T. Matthes, C Lau-Villacorta, K Unoki, CH Sung, RH Steinberg, Protection of mouse photoreceptors by survival factors in retinal degenerations, Invest. Ophthalmol Vis Sci. 39, 592–602 (1998)
E.G. Faktorovich, R.H. Steinberg, D. Yasumura, M.T. Matthes, M.M. LaVail Photoreceptor degeneration in inherited retinal dystrophy delayed by fibroblast growth factor, Nature 347,83–86 (1990)
M.M LaVail, K. Unok, D. Yasumura, M.T. Matthes, G.D. Yancopoulos, R.E. Steinberg, Multiple growth factors, cytokines and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. USA 89,11249–11253 (1992)
E.L. Berson, B. Rosner, M.A. Sandberg, K.C. Hayes, B.W. Nicholson, C. Weigel-DiFranco, W.A. Willett, Randomized trial of Vitamin A and E supplementation for retinitis pigmentosa. Arch. Ophthalmol. 111,761–772 (1993).
R.W. Massof, D. Finkelstein, Supplemental Vitamin A retards loss of ERG amplitude in retinitis pigmentosa. Arch. Ophthalmol. 111,751–754 ( 1993)
D.T. Organisciak, R.M. Darrow, I.R. Bicknell, Y.L. Jiang, M. Pickford, J.C. Blanks,Protection against retinal light damage by natural and synthetic antioxidants. In: Retinal Degenerations, edited by R.E. Anderson, J.G. Hollyfield, M.M. LaVail (Plenum Press, New York and London, 1991), pp. 189–201.
D.T. Organisciak, R.M. Darrow, Y-L. Jiang, G.E. Marak, J.C. Blanks, Protection by dimethylthiourea against retinal light damage in rats. Invest. Ophthalmol. Vis. Sci. 33,1599–1609(1992)
I. Ranchon, J.M. Gorrand, J. Cluzel, M-T. Droy-Lefaix, M. Doly Functional protection of photoreceptors from light-induced damage by dimethylthiourea and Ginkgo biloba extract. Invest. Ophthalmol. Vis. Sci. 40,1191–1199 (1999).
I. Ranchon, J. White, S. Chen, K. Alvarez, R.E. Anderson, Systemic Administration of Phenyl-N-tert-butylnitrone Protects the Retina from Light Damage. Submitted to Invest. Ophthalmol. Vis. Sci. (2000)
J.L. Poyer, R.A. Floyd, P.B. McCay, K.G. Janszen, E.R. David. Spin trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane. Biochim. Biophys. Acta, 539,402–409 (1978).
J.L. Poyer, P.B. McCay, E.K. La, K.G. Janzen, E.R. David, Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism in vitro and in vivo. Biochem. Biophys. Res. Commun. 94,1154–1160 (1980).
B.S. Winkler, M.E. Boulton, J.D. Gottsch, P. Sternberg, Oxidative damage and age related macualr degeneration, Molecular Vision, 5,32 (1999).
I. Ranchon, J.M. Gorrand, J. Cluzel, J.C. Vennat, M. Doly. Light-induced variations of retinal sensitivity in rats. Curr. Eye Res. 17, 14–23 (1998).
L.M. Rapp, M.I. Naasn, R.D. Wiegand, et al. Morphological and biochemical comparison between retinal regions having differing susceptibility to photoreceptor degeneration. In: Retinal Degeneration: Experimental and Clinical Studies, edited by M.M. La Vail, J.G. Hollyfield, R.E. Anderson (New York: Alan RLiss, 1985) pp. 421–437.
W.K. Noell, V.S. Waker, B.S. Kang, S. Berman. Retinal damage by light in rats.Invest. Ophthalmol, 5(5), 450–473 (1966).
R.D. Wiegand, N.M. Giusto, L.M. Rapp, R.E. Anderson. Evidence for rod outer segment lipid peroxidation following constant light illumination of the rat retina. Invest. Ophthalmol. Vis Sci., 24,1433–1435 (1983).
D.T. Organisciak, H.M. Wang, Z.Y. Li, M.O.M. Tso, The protective effect of ascorbate in retinal light damage of rats. Invest. Ophthalmol. Vis. Sci. 26,1580–1588 (1985).
L. Feeney, E.R. Berman, Oxygen toxicity: membrane damage by free radicals. Invest. Ophthalmol. Vis. Sci. 15, 789–792 (1976).
D.T. Organisciak, I.R. Bicknell, R.M. Darrow, The effect of L and D ascorbic acid administration on retinal tissue levels and light damage in rats. Curr. Eye. Res. 11,231–241 (1992).
W.T. Ham, H.A. Muller, J.J. Ruffolo, J.J.E. Millen, S.F. Cleary, R.K. Guerry, D Guerry, Basic mechanisms underlying the production of photochemical lesions in the mammalian retina. Curr. Eye. Res. 3,165–174 (1984).
J. Li, D.P. Edward, T.T. Lam, M.O.M. Tso, Amelioration of retinal photic injury by a combination of flunarizine and dimethylthiourea. Exp. Eye Res. 56,71–78 (1993).
Y. Kotake, H. Sang, T. Miyajima, G.L. Wallis, Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by phenyl-N-tert-butylnitrone (PBN). Biochim. Biophys. Acta, 1448:77–84 (1998).
T. Tabatabaie, K.L. Graham, A.M. Vasquez, R.A. Floyd, Y. Kotake, Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-terf-butylnitrone. Nitric Oxide 4,157–67 (2000).
H. Pogrebniak, M. Merino, S. Hahn, J. Mitchell, H. Pass, Spin trap salvage from endotoxemia: the role of cytokine down-regulation, Surgery 112,130–139 (1992).
H. Sang, G.L. Wallis, C.A. Stewar, Y. Kotake, Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by phenyl N-tert-butylnitrone (PBN). Arch. Biochem. Biophys. 363:341–348 (1999).
C.A. Stewart, K. Hyam, G. Wallis, et al. Phenyl-N-terf-butylnitrone demonstrates broad-spectrum inhibition of apoptosis-associated gene expression in endotoxin-treated rats. Arch. Biochem. Biophys. 363,:71–74 (1999).
M. Tsuji, O. Inanami, M. Kuwabara. Neuroprotective effect of alpha-phenyl-N-terf-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins. Neurosci. Lett. 282,41–44 (2000).
K.A. Robinson, C.A. Stewart, Q. Pye, R.A. Floyd, K. Hensley. Basal phosphorylation is decreased and phosphatase activity increased by an antioxidant and a free radical trap in Primary rat glia. Arch. Biochem. Biophys. 365,211–215 (1999).
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Ranchon, I., White, J., Chen, S., Alvarez, K., Kotake, Y., Anderson, R.E. (2001). Chronic Administration of Phenyl N-TERT- Butylnitrone Protects the Retina Against Light Damage. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) New Insights Into Retinal Degenerative Diseases. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1355-1_11
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DOI: https://doi.org/10.1007/978-1-4615-1355-1_11
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