Chronic Administration of Phenyl N-TERT- Butylnitrone Protects the Retina Against Light Damage
Retinal dystrophies comprise a large number of disorders characterized by a slow and progressive retinal degeneration. Most are the results of mutations expressed in either photoreceptor or retinal pigment epithelial cells. There is currently no treatment by which the primary disorder can be modified, although researchers around the world are working on different potential therapeutic approaches to treat retinal degenerations. These are based on the possibility of transfecting the photoreceptor or retinal epithelial cells with a functioning gene, transplanting photoreceptor or retinal pigment epithelial cells into the sub-retinal space, using electronic devices to stimulate the retina, or administrating drugs to enhance the repair/defense systems of the retina. Although encouraging success has been shown in animals models, gene therapy1, transplantation2 or injection of growth factors3,4,5 require invasive intraocular procedures and some have significant side effects.
KeywordsRetina NADPH Gravel Ketamine Thiourea
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