Functional Properties of Human Neocortical Neurons

A Window on the Physiopathogenesis of Seizures in Patients with Cortical Dysplasia
  • Massimo Avoli
  • Donatella Mattia
  • Andre Olivier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 497)


Knowledge of the fundamental mechanisms underlying epileptiform discharge has been greatly advanced by the use ofin vitropreparations, such as cultured and acutely dissociated neurons or brain slices (see17). In particular, thein vitrobrain-slice preparation has made it possible to study at cellular, pharmacological and molecular levels neurons and glial cells that retain their original connections. The relevance of the mechanisms discovered in animal models for understanding the physiopathogenesis of human epileptic syndromes, however, depends on the demonstration that such mechanisms do occur in the human condition as well.


Temporal Lobe Epilepsy Epileptiform Activity Focal Cortical Dysplasia Cortical Dysplasia Epileptiform Discharge 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Massimo Avoli
    • 1
  • Donatella Mattia
    • 1
  • Andre Olivier
    • 1
  1. 1.Cell Biology of Excitable Tissue Research Group Montreal Neurological Institute and Department of Neurology and NeurosurgeryMcGill UniversityMontrealCanada

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