Blood and Marrow Transplantation

  • Michelle M. Bishop
  • Helen Welsh
  • Mary Coons
  • John R. Wingard


Blood and marrow transplantation can be an extraordinary, life-saving treatment. Once considered a therapy of last resort, it has now become the standard treatment for a number of neoplastic and immunological disorders. There has been a logarithmic increase in the number of blood and marrow transplants (BMT) performed over the past two decades, as well as in the number of diseases for which BMT is considered (Bortin et al., 1992; Sobocinski et al., 1994). With a growing number of applications, along with technologic advances in supportive care, histocompatibility testing, conditioning regimens, and control of post-transplant complications and diseases, tens of thousands of transplants are performed worldwide each year. Data from the International Bone Marrow Transplant Registry and Autologous Blood and Marrow Transplant Registry suggest 15,000 to 20,000 blood and bone marrow transplants are performed in North America annually. Outcomes are steadily improving, with an estimated 10% increase in cure rate per decade seen over the past two decades.


Stem Cell Bone Marrow Bone Marrow Transplantation Marrow Transplantation Behavioral Medicine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Altmaier, E.M., Gingrich, R.D., & Fyfe, M.A. (1991). Two-year adjustment of bone marrow transplant survivors. Bone Marrow Transplantation, 7, 311–316.PubMedGoogle Scholar
  2. Andrykowski, M.A. (1994a). Psychiatric and psychosocial aspects of bone marrow transplantation. Psychosomatics, 35, 13–24.PubMedCrossRefGoogle Scholar
  3. Andrykowski, M.A. (1994b). Psychosocial factors in bone marrow transplantation: A review and recommendations for research. Bone Marrow Transplantation, 13, 357–375.PubMedGoogle Scholar
  4. Andrykowski, M.A., Brady, M.J., & Henslee-Downey, P. J. (1994). Psychosocial factors predictive of survival after allogeneic bone marrow transplantation for leukemia Psychosomatic Medicine, 56, 432–439.PubMedGoogle Scholar
  5. Andrykowski, M.A., Henslee, P.J., & Farrall, M.G. (1989). Physical and psychosocial functioning of adult survivors of allogeneic bone marrow transplantation. Bone Marrow Transplantation, 4, 75–81.PubMedGoogle Scholar
  6. Andrykowski, M.A., Schmitt, F.A., Gregg, M.E., Brady, M.J., Lamb, D.G., & Henslee-Downey, P.J. (1992). Neuropsychological impairment in adult bone marrow transplant candidates. Cancer, 70, 2288–2297.PubMedCrossRefGoogle Scholar
  7. Appelbaum, F.R. (1996). The use of bone marrow and peripheral blood stem cell transplantation in the treatment of cancer. CA: A Cancer Journal for Clinicians, 46, 142–164.CrossRefGoogle Scholar
  8. Baker, F., Curbow, B., & Wingard, J.R. (1991). Role retention and quality of life of bone marrow transplant survivors. Social Science and Medicine, 32, 697–704.PubMedCrossRefGoogle Scholar
  9. Baker, F., Zabora, J., Polland, A., & Wingard, J.R. (1999). Reintegration after bone marrow transplantation. Cancer Practice, 7, 190–197.PubMedCrossRefGoogle Scholar
  10. Beatty, P.G., Clift, R.A., Mickelson, E.M., Nisperos, B.B., Flourney, N., Martin, P.J., Sanders, J.E., Stewart, P., Buckner, CD., Storb, R., Thomas, E.D., & Hansen, J.A. (1985). Marrow transplantation from related donors other than HLA-Identical siblings. New England Journal of Medicine, 313, 765–771.PubMedCrossRefGoogle Scholar
  11. Bortin, M.M., Horowitz, M.M., Gale, R.P., Barrett, A.J., Champlin, R.E., Dicke, K.A., Gluckman, E., Kolb, H.J., Marmont, AM., Mrsic, M., Sobocinski, K.A., Weiner, R.S., & Rimm, A. A. (1992). Changing trends in allogeneic bone marrow transplantation for leukemia in the 1980s. Journal of the American Medical Association, 268, 607–612.PubMedCrossRefGoogle Scholar
  12. Brown, H.N., & Kelly, M.J. (1976). Stages of bone marrow transplantation: A psychiatric perspective. Psychosomatic Medicine, 38, 439–446.PubMedGoogle Scholar
  13. Bush, N.E., Haberman, M., Donaldson, G., & Sullivan, K.M. (1995). Quality of life of 125 adults surviving 6–18 years after bone marrow transplantation. Social Science and Medicine, 40, 479–490.PubMedCrossRefGoogle Scholar
  14. Carey, P.J., Oberst, M.T., McCubbin, M.A., & Hughes, S.H. (1991). Appraisal and caregiving burden in family members caring for patients receiving chemotherapy. Oncology Nursing Forum, 18, 1341–1348.PubMedGoogle Scholar
  15. Curbow, B., Somerfield, M.R., Baker, F., Wingard, J.R., & Legro, M.W. (1993). Personal changes, dispositional optimism, and psychological adjustment to bone marrow transplantation. Journal of Behavioral Medicine, 16, 423–443.PubMedCrossRefGoogle Scholar
  16. Dermatis, H., & Lesko, L.M. (1991). Psychosocial correlates of physician-patient communication at time of informed consent for bone marrow transplantation. Cancer Investigation, 9, 621–628.PubMedCrossRefGoogle Scholar
  17. Eilers, J.G. (1997). Family issues and perspectives. In M.B. Whedon & D. Wujcik (eds.), Blood and marrow stem cell transplantation. Boston: Jones and Bartlett Publishers.Google Scholar
  18. Fogarty, L.A., Curbow, B., Wingard, J.R., McDonnell, K., & Somerfield, M.R. (1999). Can 40 seconds of compassion reduce patient anxiety? Journal of Clinical Oncology, 17, 371–379.PubMedGoogle Scholar
  19. Fromm, K., Andrykowski, M. A., & Hunt, J. (1996). Positive and negative psychosocial sequelae of bone marrow transplantation: Implications for quality of life assessment. Journal of Behavioral Medicine, 19 ,221–240.PubMedCrossRefGoogle Scholar
  20. Futterman, A.D., Wellisch, D.K., Bond, G., & Carr, C.R. (1991). The Psychosocial Levels System: A new rating scale to identify and assess emotional difficulties during bone marrow transplantation. Psychosomatics, 32, 117–186.CrossRefGoogle Scholar
  21. Gaston-Johansson, F., Franco, T., & Zimmerman, L. (1992). Pain and psychological distress in patients undergoing autologous bone marrow transplantation. Oncology Nursing Forum, 19, 41–48.PubMedGoogle Scholar
  22. Haberman, M. (1988). Psychosocial aspects of bone marrow transplantatioa Seminars in Oncology Nursing, 4, 55–59.PubMedCrossRefGoogle Scholar
  23. Jenkins, P.L., Lester, H., Alexander, J., & Whittaker, J. (1994). A prospective study of psychosocial morbidity in adult bone marrow transplant recipients. Psychosomatics, 55, 361–367.CrossRefGoogle Scholar
  24. Kernan, N.A., Bartsch, G., Ash, R.C., Beatty, P.G., Champlin, R., Filipovich, A., Gajewski, J., Hansen, J.A., Henslee-Downey, J., McCullough, J., McGlave, P., Perkins, H.A., Phillips, G.L., Sanders, J., Stroncek, D., Thomas, E.D., & Blume, K.G. (1993). Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. New England Journal of Medicine, 328, 593–602.PubMedCrossRefGoogle Scholar
  25. Kessinger, A., & Armitage, J. (1993). The use of peripheral stem cell support of high-dose chemotherapy. In V.T. Devita, Jr. (ed.), Important advances in oncology. Philadelphia: J.B. Lippincott Co.Google Scholar
  26. Kurtzberg, J., Laughlin, M., Graham, M.L., Smith, C., Olson, J.F., Halperin, E.C., Ciocci, G., Carrier, C., Stevens, C.E., & Rubinstein, P. (1996). Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New England Journal of Medicine, 335, 157–166.PubMedCrossRefGoogle Scholar
  27. Lesko, L.M. (1989). Bone marrow transplantation. In J.C. Holland & J.H. Rowland (eds.), Handbook of psychooncology: Psychological care of the patient with cancer (pp. 163–173). New York: Oxford University Press.Google Scholar
  28. Lesko, L.M., Kern, J., & Hawkins, D.R. (1984). Psychological aspects of patients in germ-free isolation: A review of child and adult patient management literature. Medical and Pediatric Oncology, 12, 43–49.PubMedCrossRefGoogle Scholar
  29. Meyers, C.A., Weitzer, M., Byrne, K., Valentine, A., Champlin, R.E., & Przepiorka, D. (1994). Evaluation of the neurobehavioral functioning of patient before, during, and after bone marrow transplantation. Journal of Clinical Oncology, 12, 820–826.PubMedGoogle Scholar
  30. Moadel, A. B., Ostroff, J.S., & Lesko, L.M. (1997). Fertility and sexuality. In M.B. Whedon & D. Wujcik (eds.), Blood and marrow stem cell transplantation. Boston: Jones and Bartlett Publishers.Google Scholar
  31. Molassiotis, A., van den Akker, O.B.A., & Boughton, B.J. (1997). Perceived social support, family environment and psychosocial recovery in bone marrow transplant long term survivors. Social Science and Medicine, 44, 317–325.PubMedCrossRefGoogle Scholar
  32. Nademanee, A.P., Schmidt, G.M., Parker, P., Dagis, A.C., Stein, A., Snyder, D.S., O’Donnell, M., Smith, E.P., Stepan, D.E., Molina, A., Wong, K.K., Margolin, K., Somlo, G., Littrell, B., Woo, D., Sniecinski, I., Niland, J.C., & Forman, S.J. (1995). The outcome of matched unrelated donor bone marrow transplantation in patients with hematologic malignancies using molecular typing for donor selection and graft-versus-host disease prophylaxis regimen of cyclosporine, methotrexate, and prednisone. Blood, 86, 1228–1234.PubMedGoogle Scholar
  33. Rodrigue, J.R., Boggs, S.R., Weiner, R.S., & Behen, J.M. (1993). Mood, coping style, and personality functioning among adult bone marrow transplant candidates. Psychosomatics, 34, 159–165.PubMedCrossRefGoogle Scholar
  34. Rodrigue, J.R., Pearman, T.P., & Moreb, J. (1999). Morbidity and mortality following bone marrow transplantation: Predictive utility of pre-BMT affective functioning, compliance, and social support stability. International Journal of Behavioral Medicine, 6, 241–254.PubMedCrossRefGoogle Scholar
  35. Sasaki, T., Akaho, R., Sakamaki, H., Akiyama, H., Yoshino, M., Hagiya, K., & Atsumi, M. (2000). Mental disturbances during isolation in bone marrow transplant patients with leukemia. Bone Marrow Transplantation, 25, 315–318.PubMedCrossRefGoogle Scholar
  36. Shapiro, D. (2000). Mom’s marijuana: Insights about living. New York: Harmony Books.Google Scholar
  37. Sobocinski, K.A., Horowitz, M.M., Rowlings, P.A., Zhang, M.J„ Nugent, M.L., Passweg, J.R., Armitage, J.O., Gale, R.P., & Bortin, M.M. (1994). Bone marrow transplantation - 1994: A report from the International Bone Marrow Transplant Registry and the North American Autologous Bone Marrow Transplant Registry. Journal of Hematotherapy, 3, 95–102.PubMedCrossRefGoogle Scholar
  38. Syrjala, K. (1995). Meeting the psychological needs of recipients and families. In P. Buschel & M. Whedon (eds.), Bone marrow transplantation: Administrative and clinical strategies (pp. 283–301). Boston: Jones and Bartlett Publishers.Google Scholar
  39. Syrjala, K.L., Chapko, M.K., Vitaliano, P.P., Cummings, C., & Sullivan, K.M. (1993). Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplantation, 11, 319–327.PubMedGoogle Scholar
  40. Wagner, J.E., Rosenthal, J., Sweetman, R., Shu, X.O., Davies, S.M., Ramsay, N.K., McGlave, P.B., Sender, L., & Cairo, M.S. (1996). Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: Analysis of engraftment and acute graft-versus-host disease. Blood, 88, 795–802.PubMedGoogle Scholar
  41. Walch, S., & Ahles, T.A. (1997). Psychosocial effects: Pretransplant and acute treatment phase. In M.B. Whedon & D. Wujcik (eds.), Blood and marrow stem cell transplantation. Boston: Jones and Bartlett Publishers.Google Scholar
  42. Wettergren, L., Langius, A., Bjorkholm, M., & Bjorvell, H. (1997). Physical and psychosocial functioning in patients undergoing autologous bone marrow transplantation-a prospective study. Bone Marrow Transplantation, 20, 497–502.PubMedCrossRefGoogle Scholar
  43. Wingard, J.R. (1994). Functional ability and quality of life of patients after allogeneic bone marrow transplantation. Bone Marrow Transplantation, 14, S29–S33.PubMedCrossRefGoogle Scholar
  44. Wingard, J.R. (1998). Quality of life following bone marrow transplantation. Current Opinion in Oncology, 10, 108–111.PubMedCrossRefGoogle Scholar
  45. Wingard, J.R., Curbow, B. Baker, F., Zabora, J., & Piantadosi, S. (1992). Sexual satisfaction in survivors of bone marrow transplantation. Bone Marrow Transplantation, 9, 185–190.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Michelle M. Bishop
  • Helen Welsh
  • Mary Coons
  • John R. Wingard

There are no affiliations available

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