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Induction of Apoptosis in Murine Coronavirus-Infected 17CI-1 Cells

  • Chun-Jen Chen
  • Sungwhan An
  • Shinji Makino
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Apoptosis is an important process in the development and homeostasis of multicellular organisms (Jacobson et al 1997). In most cases, apoptosis is executed by activating a proteolytic system involving a family of caspases. Caspases participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in cell death (Cohen 1997). Apoptosis also represents a highly efficient defence mechanism against virus infection; apoptosis aids in removal of viral proteins and nucleic acids by the infected host.

Keywords

Mouse Hepatitis Virus Proapoptotic Signal Transmissible Gastroenteritis Virus Unidentified Substance Fetal Calf Serum Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Belyavskyi, M., Belyavskaya, E., Levy, G. A., and Leibowitz, J. L., 1998, Coronavirus MHV-3-induced apoptosis in macrophages. Virology 250:41–49.CrossRefGoogle Scholar
  2. Cohen, G. M., 1997, Caspases: the executioners of apoptosis. Biochem. J. 326:1–16.PubMedGoogle Scholar
  3. Eleouet, J.-F., Chilmonczyk, S., Besnardeau, L., and Laude, H., 1998, Transmissible gastroenteritis Coronavirus induces programmed cell death in infected cells through a caspase-dependent pathway. J. Virol. 72:4918–4924.PubMedGoogle Scholar
  4. Hinshaw, V. S., Olsen, C. W., Dybdahl-Sissoko, N., and Evans, D., 1994, Apoptosis: a mechanism of cell killing by influenza A and B viruses. J. Virol. 68:3667–3673.PubMedGoogle Scholar
  5. Hirano, N., Fujiwara, K., Hino, S., and Matsumoto, M., 1974, Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch. Fesamte Virusforch. 44:298–302.CrossRefGoogle Scholar
  6. Jacobson, M. D., Weil, M., and Raff, M. C., 1997, Programmed cell death in animal development. Cell 88:347–354.PubMedCrossRefGoogle Scholar
  7. Sturman, L. S., Holmes, K. V., and Behnke, J., 1980, Isolation of Coronavirus envelope glycoproteins and interaction with the viral nucleocapsid. J. Virol 33:449–462.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Chun-Jen Chen
    • 1
  • Sungwhan An
    • 2
  • Shinji Makino
    • 1
    • 2
  1. 1.Department of Microbiology, and ImmunologyThe University of Texas Medical Branch at GalvestonGalvestonUSA
  2. 2.Department of Microbiology and Institute for Cellular and Molecular BiologyThe University of Texas at AustinUSA

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