Influence of Changes in the Population of Target Cells and Appearance of Specific Antibodies on the Replication of Porcine Reproductive and Respiratory Syndrome Virus in the Lungs of Pigs

  • H. J. Nauwynck
  • G. G. Labarque
  • K. Van Reeth
  • M. B. Pensaert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 494)

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a new arterivirus that caused an epidemic of reproductive failure and respiratory problems in pigs, all over the world in the late eighties and early nineties.

Keywords

Acetone Titration Heparin Cytosol Hines 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Christopher-Hennings, J., Nelson, E. A., Hines, R. J., Nelson, J. K., Swenson, S. L., Zimmerman, J. J., Chase, C. C. L., Yaeger, M. J., and Benfield, D. A., 1995, Persistence of porcine reproductive and respiratory syndrome virus in serum and semen of adult boars, Journal of Veterinary Diagnostic Investigation, 7:456–464.PubMedCrossRefGoogle Scholar
  2. Drew, T. W., Meulenberg, J. J. M., Sands, J. J. and Paton, D. J., 1995, Production, characterization and reactivity of monoclonal antibodies to porcine reproductive and respiratory syndrome virus, Journal of General Virology, 76:1361–1369.PubMedCrossRefGoogle Scholar
  3. Duan, X., Nauwynck, H. J., and Pensaert, M. B., 1997a, Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus, Veterinary Microbiology, 56:9–19.PubMedCrossRefGoogle Scholar
  4. Duan, X., Nauwynck, H. J., and Pensaert, M. B., 1997b, Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to PRRSV, Archives of Virology, 142:2483–2497.PubMedCrossRefGoogle Scholar
  5. Duan, X., Nauwynck, H. J., Favoreel, H. W., and Pensaert, M. B., 1998, Identification of a putative virus receptor for porcine reproductive and respiratory syndrome virus on porcine alveolar macrophages, Journal of Virology, 72:4520–4523.PubMedGoogle Scholar
  6. Labarque, G. G., Nauwynck, H. J., Van Reeth, K. and Pensaert, M. B., 2000, Apoptosis in the lungs of pigs during an infection with a European strain of porcine reproductive and respiratory syndrome virus, Advances in Experimental Medicine and biology, (see elsewhere in this volume).Google Scholar
  7. Mengeling, W. L., Lager, K. M., and Vorwald, A. C., 1995, Diagnosis of porcine reproductive and respiratory syndrome, Journal of Veterinary Diagnostic Investigation, 7:3–16.PubMedCrossRefGoogle Scholar
  8. Nauwynck, H. J., Duan, X., Favoreel, H. W., Van Oostveldt, P., and Pensaert, M. B., 1999, Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis, Journal of General Virology 80:297–305.PubMedGoogle Scholar
  9. Pescovitz, M. D., Lunney, J. K., and Sachs, D. H., 1984, Preparation and characterization of monoclonal antibodies reacting with porcine PBL, Journal of Immunology, 133:368–375.Google Scholar
  10. Swenson, S. L., Hill, H. T., Zimmerman, J. J., Evans, L. E., Landgraf, J. G. Wills, R. W., Sanderson, T. P., McGinley, M. J., Brevik, A. K., Ciszewski, D. K. and Frey, M. L., 1994, Excretion of porcine reproductive and respiratory syndrome virus in semen after experimentally induced infection in boars, Journal of the American Veterinary Medical Association, 204:1943–2194.PubMedGoogle Scholar
  11. Vanderheijden, N., Delputte, P., Nauwynck, H. J., and Pensaert, M. B., 2000, Effect of heparin on the entry of porcine reproductive and respiratory syndrome virus into alveolar macrophages, Advances in Experimental Medicine and biology, (see elsewhere in this volume).Google Scholar
  12. Van Reeth, K., Labarque, G., Nauwynck H. J., and Pensaert, M. B., 1999, Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity, Research in Veterinary Science, 67:47–52.PubMedCrossRefGoogle Scholar
  13. Wensvoort, B., Terpstra, C., Pol, J. M. A., ter Laak, E. A., Bloemraad, M., de Kluyver, E. P., Kragten, C., van Buiten, L., den Besten, A., Wagenaar, F., Broekhuijsen, J. M., Moonen, P. L. J., Zetstra, T., de Boer, E. A., Tibben, H. J., de Jong, M. F., van’t Veld, P., Groenland, G. J. R., van Gennep, J. A., Voets, M. T., Verheijden, J. H. M., and Braamskamp, J., 1991, Mystery swine disease in the Netherlands: the isolation of Lelystad virus, Veterinary Quarterly, 13:121–130.PubMedCrossRefGoogle Scholar
  14. Wills, R. W., Zimmerman, J. J., Yoon, K.-J., Swenson, S. L., McGinley, M. J., Hill, H. T., Piatt, K. B., Christopher-Hennings, J., and Nelson, E. A., 1997, Porcine reproductive and respiratory syndrome virus: a persistent infection, Veterinary Microbiology, 55:231–240.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • H. J. Nauwynck
    • 1
  • G. G. Labarque
    • 1
  • K. Van Reeth
    • 1
  • M. B. Pensaert
    • 1
  1. 1.Laboratory of Virology, Faculty of Veterinary MedicineGhent UniversityMerelbekeBelgium

Personalised recommendations