Abstract
The mature Coronavirus spike is a large, oligomeric, type I integral membrane glycoprotein that projects about 20 nm from the surface of infected cells and virions. In this extracellular position, the spikes function to bind the cellular receptors extending from opposing membranes. Following receptor binding, largely hypothetical structural changes take place to generate spike conformations that are capable of mediating fusion of the juxtaposed membranes. Membrane fusion creates pores for entrance of genomes into uninfected cells.
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Gallagher, T.M. (2001). Murine Coronavirus Spike Glycoprotein. In: Lavi, E., Weiss, S.R., Hingley, S.T. (eds) The Nidoviruses. Advances in Experimental Medicine and Biology, vol 494. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1325-4_30
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DOI: https://doi.org/10.1007/978-1-4615-1325-4_30
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