Abstract
Na,K-ATPase actively translocates potassium (K) into and sodium (Na) out of the cell in a 2:3 relationship, which contributes to the electrical properties of the cells. The influence of the Na,K-ATPase on the membrane potential is essential for excitability and contractility in skeletal muscles and myocardium. The transmembraneous gradients of Na and K also serves as a source of energy storage for secondary active transport of nutrients and other ions including glucose, amino acids, vitamins, Ca and H. The Na and K gradients are also of major importance for maintenance of osmotic balance and cell volume, since cations are of major importance for maintaining osmolarity of mammalian cells. In animals as well as in humans diabetes is associated with reduced skeletal muscle Na,K-ATPase function. On this basis a variety of muscular disturbances seen in diabetes maybe related to regulation of muscular Na,K-ATPase.
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© 2001 Springer Science+Business Media New York
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Bundgaard, H., Kjeldsen, K. (2001). Regulation of Myocardial and Skeletal Muscle Na,K-ATPase in Diabetes Mellitus in Humans and Animals. In: Angel, A., Dhalla, N., Pierce, G., Singal, P. (eds) Diabetes and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 498. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1321-6_40
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DOI: https://doi.org/10.1007/978-1-4615-1321-6_40
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