Endothelins in the Microvasculature and Heart in Diabetes

  • Subrata Chakrabarti
  • Shali Chen
  • Terry Evans
  • Morris Karmazyn
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 498)

Abstract

Diabetes and its complications impose a global health problem of enormous proportion1. One of the most challenging problems during the last few decades has involved the elucidation of the pathogenetic mechanisms responsible for chronic diabetic complications, in an attempt to develop targeted treatment strategies. The establishment of hyperglycemia as the key initiating factor for the development of chronic diabetic complications is a milestone in diabetes research2. However the mechanisms, at the cellular level, by which hyperglycemia affects tissue structures and functions leading to diabetic complications remain poorly understood. Exploration of these mechanisms are challenging due to their complex nature and are of vital importance as they will form the backbone for the development of adjuvant treatment strategies. Chronic complications affects multiple organ systems in diabetes. In this article we will address some of the pathogenetic mechanisms of diabetic heart disease as well as diabetic retinopathy where microvascular affection is of major pathogenetic importance.

Keywords

Retina Histamine Fructose Cardiol Galactose 

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Subrata Chakrabarti
    • 1
  • Shali Chen
    • 1
  • Terry Evans
    • 1
  • Morris Karmazyn
    • 2
  1. 1.Department of PathologyThe University of Western Ontario LondonOntarioCanada
  2. 2.Department of Pharmacology and ToxicologyThe University of Western OntarioLondonCanada

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