Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System

  • Craig H. Gelband

Abstract

Potassium channels are key regulators of resting membrane potential and tightly control the patterns of electrical excitability in cardiac myocytes and vascular smooth muscle cells. Under typical conditions of physiological variability in vivo, the level of K+ channel expression in cardiovascular membranes appears to be dynamically regulated to permit normal tissue-specific electrophysiological function. However, in some cardiovascular pathologies, as reviewed in other chapters in this book, alterations in K+ channels appear to contribute to, rather than buffer, abnormalities in cell excitation patterns. For example, mutations in myocardial K+ channels are linked to cardiac arrhythmias and sudden death (see Chapters 17 and 36), and in the pulmonary vasculature, the downregulation of K+ channels may contribute to the etiology of primary pulmonary hypertension (see Chapters 27 and 40). Thus, it is not surprising that tremendous efforts are being directed toward understanding the molecular mechanisms that govern the gene and protein expression levels of K+ channel subunits, as well as the phenotypic profile of K+ channels in cardiac yocytes and vascular smooth muscle cells. Similarly, new therapeutic approaches are being considered to treat ion channel abnormalities in cardiovascular disease states.

Keywords

Permeability Attenuation Polypeptide Angiotensin Histamine 

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Craig H. Gelband
    • 1
  1. 1.Department of Physiology, College of MedicineUniversity of FloridaGainesvilleUSA

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