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Potassium Channels in Cardiovascular Biology pp 753–772Cite as

The Molecular Basis of the Long QT Syndrome

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Abstract

Sudden cardiac death is an important cause of cardiovascular mortality in the United States (Kannel et al., 1987; Willich et al., 1987). Cardiac arrhythmias, specifically ventricular tachyarrhythmias, are presumed to be responsible for the majority of these deaths. Recent advances in molecular genetics have allowed the identification of several genes responsible for one form of inherited arrhythmia, the long QT syndrome (LQTS). These findings have furthered our understanding of the molecular basis of the cardiac action potential and offered insights into structure-function relationships of cardiac ion channels.

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Authors and Affiliations

  1. Department of Pediatrics and Medicine, Eccles Program in Human Molecular Biology and Genetics, University of Utah and Primary Children’s Medical Center, Salt Lake City, Utah, 84113, USA

    Martin Tristani-Firouzi & Michael C. Sanguinetti

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  1. Martin Tristani-Firouzi
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  2. Michael C. Sanguinetti
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Editors and Affiliations

  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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© 2001 Springer Science+Business Media New York

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Tristani-Firouzi, M., Sanguinetti, M.C. (2001). The Molecular Basis of the Long QT Syndrome. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_36

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  • DOI: https://doi.org/10.1007/978-1-4615-1303-2_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5487-1

  • Online ISBN: 978-1-4615-1303-2

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