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Overview: The Role of Potassium Channels in Cardiac Arrhythmias

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Potassium Channels in Cardiovascular Biology

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Abstract

Potassium channels play an important role in the repolarization process of the cardiac action potential and, hence, determine action potential duration and myocardial refractoriness. Recent molecular, genetic, and electrophysiological studies in humans and in animal models have provided insights into the role of K+ channels in arrhythmogenesis. Changes in the functional expression or biophysical properties of K+ channels caused by pathophysiologic conditions, congenital mutations (inherited long QT syndrome), or pharmacologic intervention (acquired long QT syndrome) cause abnormal repolarization of the action potential, increased electrical dispersion, and an increased propensity for arrhythmia.

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  1. Department of Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, 08543-4000, USA

    Albert J. D’ Alonzo, Paul C. Levesque & Michael A. Blanar

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  3. Michael A. Blanar
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  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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© 2001 Springer Science+Business Media New York

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D’ Alonzo, A.J., Levesque, P.C., Blanar, M.A. (2001). Overview: The Role of Potassium Channels in Cardiac Arrhythmias. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_35

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  • DOI: https://doi.org/10.1007/978-1-4615-1303-2_35

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5487-1

  • Online ISBN: 978-1-4615-1303-2

  • eBook Packages: Springer Book Archive

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