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Activation of Vascular Smooth Muscle K+Channels by Endothelium-Derived Factors

  • Chapter
Potassium Channels in Cardiovascular Biology

Abstract

Endothelial cells synthesize and release vasoactive mediators in response to various neurohumoral substances (e.g., acetylcholine, ATP, bradykinin, thrombin) and physical stimuli (e.g., shear stress exerted by the flowing blood) (Furchgott and Vanhoutte, 1989). Nitric oxide (NO) produced by the L-arginine—NO synthase pathway and prostacyclin produced from arachidonic acid by cyclooxygenase have been identified as potent endothelium-derived vasodilators (Moncada et al., 1976; Moncada and Vane, 1979; Furchgott and Zawadzki, 1980; Palmer et al., 1987, Palmer 1988). However, not all endothelium-dependent relaxations can be fully explained by the release of either NO or prostacyclin. Indeed, another unidentified substance(s) which hyperpolarizes the underlying vascular smooth muscle cells, termed endothelium-derived hyperpolarizing factor (EDHF), may contribute to endothelium-dependent relaxations (Furchgott and Vanhoutte, 1989; Komori and Vanhoutte, 1990; Félétou and Vanhoutte, 1996a; Mombouli and Vanhoutte, 1997).

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Authors and Affiliations

  1. Département de Diabétologie, Institut de Recherches Servier, 92150, Suresnes, France

    Michel Félétou

  2. Institut de Recherches Internationales Servier, 92410, Courbevoie, France

    Paul M. Vanhoutte

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  1. Michel Félétou
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  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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Félétou, M., Vanhoutte, P.M. (2001). Activation of Vascular Smooth Muscle K+Channels by Endothelium-Derived Factors. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_34

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