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Single-Channel Properties of Ca2+ -Activated K+Channels in the Vascular Endothelium

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Potassium Channels in Cardiovascular Biology

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Abstract

The vascular endothelium performs a number of its functions through the release of several physiologically active mediators (Furchgott and Vanhoutte, 1989). These include nitric oxide (NO) and prostaglandin I2 (PGI2), which are involved in the regulation of vascular tone and the inhibition of platelet activity. The generation and release of both of these mediators is influenced by the cytosolic calcium concentration ([Ca2+] i ) in the endothelial cells (Moncada et al., 1991; Hallam et al., 1988). Thus, endothelium-dependent vasodilators act, at least in part, through the modulation of endothelial [Ca2+] i . The [Ca2+] i - also influences endothelial barrier properties (Rotrosen and Gallin, 1986).

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Cambridge, Cambridge, CB2 3EG, UK

    Stewart O. Sage

  2. The Bogomoletz Institute of Physiology, Ukrainian Academy of Sciences, Kiev 24, 252601 GSP, Ukraine

    Sergey M. Marchenko

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  1. Stewart O. Sage
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  2. Sergey M. Marchenko
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Editor information

Editors and Affiliations

  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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Sage, S.O., Marchenko, S.M. (2001). Single-Channel Properties of Ca2+ -Activated K+Channels in the Vascular Endothelium. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_32

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  • DOI: https://doi.org/10.1007/978-1-4615-1303-2_32

  • Publisher Name: Springer, Boston, MA

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