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Potassium Channels in the Coronary Circulation

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Potassium Channels in Cardiovascular Biology

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Abstract

The heart consumes more oxygen per gram of tissue than any other organ of the body. One of the most striking features of the coronary circulation is the close relationship between the requirement for oxygen and metabolic substrates and the magnitude of coronary blood flow. The mechanisms underlying this interaction are still poorly understood but seem to involve adaptive regulatory processes in the coronary macro-and microvasculature. Daut et al. (1990) first demonstrated that hypoxic vasodilation in isolated, perfused guinea pig hearts is prevented by glibenclamide (Fig. 1), suggesting a role for adenosine triphosphate-sensitive K+ (KATP) channels, in the regulation of adaptive processes in the coronary macro- and microvasculature and making the investigation of KATP channels in the coronary circulation clinically relevant.

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Authors and Affiliations

  1. Franz Volhard Clinic at the Max Delbrück Center for Molecular Medicine, Charité University Hospitals, Humboldt University Berlin, D-13125, Berlin, Germany

    Maik Gollasch

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  1. Maik Gollasch
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  1. Walter McKenzie Health Science Centre, University of Alberta Hospital, Edmonton, Alberta, Canada

    Stephen L. Archer

  2. Medical College of Wisconsin, Milwaukee, Wisconsin, USA

    Nancy J. Rusch

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Gollasch, M. (2001). Potassium Channels in the Coronary Circulation. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_29

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  • DOI: https://doi.org/10.1007/978-1-4615-1303-2_29

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