Clavanins and Styelins, α-Helical Antimicrobial Peptides from The Hemocytes of Styela clava
Many different antimicrobial peptides are expressed by mammalian and avian leukocytes [reviewed in 1]. These peptides, which serve as endogenous antibiotics, are amphipathic and cationic molecules comprised of 12-40 amino acid residues. Most, if not all, target and perturb microbial membranes, often by forming voltage-gated channels. Many antimicrobial peptides have a-helical secondary structures, while others contain cystine-stabilized (β-sheets. A few antimicrobial peptides are histidine or prolinerich.
KeywordsAntimicrobial Peptide Polar Residue Radial Diffusion Assay Methyl Tyrosine Apolar Residue
Unable to display preview. Download preview PDF.
- 1.Lehrer, R.I., Revins, C.L. and Ganz, T. Defensins and Other Antimicrobial Peptides. 1999. in Mucosal Immunology, Second Edition. Edited by P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R.. McGhee and J. Bienenstock. Academic Press, N.Y. pp 89–100.Google Scholar
- Zhao, C., Liaw, L., Lee, I.H. and R.I. Lehrer. 1997. cDNA cloning of clavanins: antimicrobial peptides of tunicate hemocytes. FEBS Lett. 410:490–492.Google Scholar
- Zhao, C., Liaw, L., Lee, I.H., and R.I. Lehrer. 1997. eDNA cloning of three cecropin-like antimicrobial peptides (Styelins) from the tunicate, Styela clava. FEBS Lett. 412:144–148.Google Scholar
- 7.Steinberg, D. and R.I. Lehrer. 1997. Designer Assays for Antimicrobial Peptides: Disputing the “One Size Fits All” Theory, in Methods in Molecular Biology, W. M. Shafer, editor, Humana Press, Totowa, N.J. pp. 169–187.Google Scholar
- 8.Turner, J., Cho, Y., Dinh, N., Waring, A.J. and Lehrer, R.I. 1998. Activities ofLL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agts Chemother 42:2206–2214.Google Scholar