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Clavanins and Styelins, α-Helical Antimicrobial Peptides from The Hemocytes of Styela clava

  • Robert I. Lehrer
  • In Hee Lee
  • Lorenzo Menzel
  • Alan Waring
  • Chengquan Zhao
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 484)

Abstract

Many different antimicrobial peptides are expressed by mammalian and avian leukocytes [reviewed in 1]. These peptides, which serve as endogenous antibiotics, are amphipathic and cationic molecules comprised of 12-40 amino acid residues. Most, if not all, target and perturb microbial membranes, often by forming voltage-gated channels. Many antimicrobial peptides have a-helical secondary structures, while others contain cystine-stabilized (β-sheets. A few antimicrobial peptides are histidine or prolinerich.

Keywords

Antimicrobial Peptide Polar Residue Radial Diffusion Assay Methyl Tyrosine Apolar Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Robert I. Lehrer
    • 1
    • 2
  • In Hee Lee
    • 1
  • Lorenzo Menzel
    • 1
  • Alan Waring
    • 1
    • 3
  • Chengquan Zhao
    • 1
  1. 1.Molecular Host Defense Section, Dep’t of Medicine’UCLA School of MedicineLos Angeles
  2. 2.Molecular Biology InstituteUCLA School of MedicineLos Angeles
  3. 3.Dep’t of PediatricsUCLA School of MedicineLosAngeles

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