Paralytic and Plasmatocyte Spreading Peptide From Manduca sexta
A family of hemolymph peptides with diverse biological activities has been identified in several Lepidopteran species. These peptides can cause rapid paralysis (Skinner et al., 1991), block growth and development (Hayakawa, 1991), and stimulate plasmatocyte spreading and aggregation (Clark et al., 1997). The 23-residue peptides are produced from larger inactive precursors in plasma. The precursor proteins are rapidly converted by a specific proteolysis to active molecules upon bleeding and perhaps after parasitization or infection.
KeywordsReversed Phase HPLC Lepidopteran Species Lepidopteran Insect Diverse Biological Activity Heliothis Virescens
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- Skinner, W.S., Dennis, RA, Li, J.P., Summerfelt, R.M., Carney, R.L., and Quistad, G.B. (1991) Isolation and identification of paralytic peptides from hemolymph of the lepidopteran insects Manduca sexta, Spodoptera exigua, and Heliothis virescens. J. Biol. Chem. 266, 12873–12877.Google Scholar