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Individual-Specific Repertoires of Immune Cells SRCR Receptors in the Purple Sea Urchin(S. Purpuratus)

  • Zeev Pancer
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 484)

Abstract

Invertebrates comprise the vast majority of contemporary animal species, yet their immune system been poorly characterized, especially at the molecular level (Klein, 1995). Nevertheless, invertebrates possess elaborate mechanisms to identify and eliminate life-threatening pathogens (reviews by: Smith and Davidson, 1992; Sima, 1993; Smith and Davidson, 1994; Hoffmann et al., 1996; Medzhitov and Janeway, 1998). While the evolutionary elaboration of anti-pathogen responses in a hostile environment seems inevitable, the evolution of invertebrate and vertebrate individuality determining systems presents an evolutionary enigma. A basic function of the vertebrate immune system is to maintain a representative “image” of the cells and molecules of which individuals consist, and to mediate in the conflict between cooperation and competition among individual cells. The development and elaboration of such molecular and cellular surveillance systems might have accompanied the emergence of multicellular animals, along with the evolution of higher levels of molecular and cellular complexity.

Keywords

Bacterial Artificial Chromosome Scavenger Receptor Activate Leukocyte Cell Adhesion Molecule Macrophage Scavenger Receptor Vertebrate Immune System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Zeev Pancer
    • 1
  1. 1.Department of BiologyCalifornia Institute of TechnologyPasadena

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