Advertisement

Collagenous Lectins in Tunicates and the Proteolytic Activation of Complement

  • David Raftos
  • Peter Green
  • Deepika Mahajan
  • Rebecca Newton
  • Sarina Pearce
  • Rodney Peters
  • Jennifer Robbins
  • Sham Nair
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 484)

Abstract

Complement activation in vertebrates has traditionally been associated with the classical (antibody mediated) or alternative (spontaneously hydrolytic) pathways. Recently, a new mechanism of complement activation has been identified in which a collagenous lectin (collectin), mannose binding protein (MBP) and its associated serine protease (MASP) activate the central component of the complement system, C3 (Epstein, et al., 1996, Holmskov, et al., 1994, Hoppe and Reid, 1994, Lu, 1997). Two components of this lectin-mediated complement pathway have already been identified in invertebrates. Echinoderms express a C3 homologue and a number of other complement components, whilst a MASP-like serine protease and a C3 homologue have been identified in tunicates (Al-Sharif, et al., 1998, Azumi, et al., 1993, Nonaka, et al., 1998, Smith, et al., 1996, Smith, et al., 1998).

Keywords

Complement Component Carbohydrate Binding Opsonic Activity High Order Oligomer Amino Acid Composition Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Al-Sharif WZ, Sunyer JO., Lambris JD Smith, LC. Sea urchin coelomocytes specfically express a homologue of the complement component C3. J. Immunol. 1998;160:2983–2997PubMedGoogle Scholar
  2. Azumi K, Satoh NYokosawa H. Functional and structural characterization of hemocytes of the solitary ascidian, Halocynthia roretzi. Journal of Experimental Biology. 1993;265:309–316.Google Scholar
  3. Crouch E, Persson A, Chang D, Heuser J. Molecular structure of pulmanory surfactat protein D (SP-D). J. Biol. Chem. 1994;269:17311–17319PubMedGoogle Scholar
  4. Davis AE, Lachmann N. Bovine conglutinin is a collagen-like protein. Biochemistry. 1984;23:2139–2144 Drickamcr K, Taylor ME. Biology of animal lectins. Annu. Rev. Cell Biol. 1993;9:237–264CrossRefGoogle Scholar
  5. Epstein J, Eichbaum Q, Sheriff S, Ezekowitz RAB. The collectins in innate immunity. Current Opinions Immunol. 1996;8:29–35CrossRefGoogle Scholar
  6. Holmskov U, Laursen SB, Malhotra R, Wiedemann H, Timpl R, Stuart GR, Tomoe H, Madsen PS, Reid KBM, Jensenius JC. Comparative study of the structural and functional properties of a bovine plasma C-type lectin, collectin-43, with other collectins. Biochem. J. 1995;305:889–896PubMedGoogle Scholar
  7. Holmskov U, Malhotra R, Sim RB, Jensenius JC. Collectins: collagenous C-type lectins of the innate immune defense system. Immunol. Today. 1994;15:67–74PubMedCrossRefGoogle Scholar
  8. Hoppe, HJReid, KBM. Collectins - Soluble proteins containing collagenous regions and lectin domains and their roles in innate immunty. Protein Science. 1994;3:1143–1158CrossRefGoogle Scholar
  9. Laursen SB, Hedemand JE, Thiel S, Willis AC, Skriver E, Madsen PS, Jensenius JC. Collectin in a non-mammalian species: isolation and charaterisation ofmannan binding protein (MBP) from chicken serum. Glycobiology. 1995;5:553–561PubMedCrossRefGoogle Scholar
  10. Lu J, Willis AC, Reid KBM. Purification, characterisation and cDNA cloning of human lung surfactant protein D. Biochem. J. 1992;284:795–802Google Scholar
  11. Lu JH. Collectins - Collectors of microorganisms for the innate immune system. Bioessays. 1997;19:509–518PubMedCrossRefGoogle Scholar
  12. Matsushita M, Fujita T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C l s-like serine protease. J. Exp. Med. 1992;176:1497–1502PubMedCrossRefGoogle Scholar
  13. Nonaka M, Azumi K, Ji X, Namikawa-Yamada C, Sasaki M, Saiga H, Dodds AW, Sekine H, Homma MK, Matsushita M, Endo Y, Fujita T. Opsonic complement component C3 in the solitary ascidian, Halocynthia roetzi. J. Immunol. 1998;162:387–391Google Scholar
  14. Reid, KBM. Complete amino acid sequences of the three collagen-like regions present in subcomponent Clq of the first component of human complement. Biochem. J. 1979; 179:367–371Google Scholar
  15. Reid KBM, Gagnon J, Frampton J. Completion of the amino acid sequences of the A and B chains of subcomponent Clq of the first component of human complement. Biochem. J. 1982;203:559–569PubMedGoogle Scholar
  16. Sellar GC, Blake DJ, Reid KBM. Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent Clq. The complete derived amino acid sequence of human Clq. Biochem. J. 1991; 274:481–490PubMedGoogle Scholar
  17. Smith LC, Chang L, Britten lu, Davidson EH. Sea urchin genes expressed in activated coelomocytes are identified by expressed sequence tags. J. Immunol. 1996;156:593–602PubMedGoogle Scholar
  18. Smith LC, Shih C-S Dachenhausen SG. Coelomocytes express SpBf, a homologue of Factor B, the second component in the sea urchin complement system. J. Immunol. 1998;161:6784–6793PubMedGoogle Scholar
  19. Tan SM, Chung MCM, Kon OL, Thiel S, Lee SH, Lu J. Improvement on the purification of mannanbinding lectin and demonstration of its Ca“ association with a Cls-like serine protease. Biochem. J. 1996;319:329–332Google Scholar
  20. Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid, KBM, Jensenius JC. A second serine protease associated with mannan-binding lectin that activates complement. Nature. 1997;386:506–510PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • David Raftos
    • 2
  • Peter Green
    • 2
  • Deepika Mahajan
    • 2
  • Rebecca Newton
    • 1
  • Sarina Pearce
    • 2
  • Rodney Peters
    • 2
  • Jennifer Robbins
    • 2
  • Sham Nair
    • 2
  1. 1.Department of AnatomyUniversity of California San FranciscoSan Francisco
  2. 2.Dept of Biological SciencesMacquarie UniversityAustralia

Personalised recommendations