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A Family of C-Type Lectins in Manduca sexta

  • Xiao-Qiang Yu
  • Michael R. Kanost
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 484)

Abstract

Insects have a rapid and effective immune system against microbial infections (Gillespie et al., 1997) that shares common characteristics with the innate immune system of vertebrates. It also consists of humoral and cellular responses. In the cellular responses such as phagocytosis, nodule formation and encapsulation, hemocytes play important roles. In insect humoral responses, many hemolymph proteins are involved. These proteins include a group of antimicrobial proteins/peptides, lectins, and cell adhesion proteins.

Keywords

Innate Immune System Cell Adhesion Protein Activate Phenol Oxidase Hemolymph Protein Ligand Binding Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chen, C., Durrant, J., Newton, R. P. and Ratcliffe, N.A. (1995) A study of novel lectins and their involvement in the activation of the prophenoloxidase system in Blaberus discoidalis. Biochem. J. 310, 23–31.Google Scholar
  2. Gillespie, J. P., Kanost, M. R. and Trenczek, T. (1997) Biological mediators of insect immunity. Annu. Rev.Entorno!. 42, 611–643.CrossRefGoogle Scholar
  3. Janeway Jr., C. A. (1992) The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13, 11–16.PubMedCrossRefGoogle Scholar
  4. Jomori, T. and Natori, S. (1992) Function of the lipopolysaccharide-binding protein of Periplaneta americana as an opsonin. FEBS Letters 296, 283–286.PubMedCrossRefGoogle Scholar
  5. Koizumi, N., Imamura, M., Kadotani, T., Yaoi, K., Iwahana, H. and Sato, R (1999) Thelipopolysaccharidebinding protein participating in hemocyte nodule formation in the silkworm Bombyx mori is a novel member of the C-type lectin superfamily with two different tandem carbohydrate-recognition domains. FEBS Letters 443, 139–143.PubMedCrossRefGoogle Scholar
  6. Shin, S. W., Park, S.-S., Park, D.-S., Kim, M. G., Kim, S. C., Brey, P. T. and Park, H.-Y. (1998) Isolation and characterization of immune-related genes from the fall webworm, Hyphantria cunea, using PCR-based differential display and subtractive cloning. Insect Biochem. Malec. Biol. 28, 827–837.CrossRefGoogle Scholar
  7. Weis, W. I., Taylor, M. E. and Drickamer, K. (1998) The C-type lectin superfamily in the immune system. Immunol. Rev. 163, 19–34.PubMedCrossRefGoogle Scholar
  8. Wilson, R., Chen, C. and Ratcliffe, N.A. (1999) Innate immunity in insects: the role of multiple, endogenous serum lectins in the recognition of foreign invaders in the cockroach, Blaberus discoidalis. J. Immunol. 162, 1590–1596.Google Scholar
  9. Yu, X.-Q., Gan, H. and Kanost, M. R. (1999) Immulectin, an inducible C-type lectin from an insect, Manduca sexta, stimulates activation of plasma prophenol oxidase. Insect. Biochem. Molec. Biol. In press.Google Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Xiao-Qiang Yu
    • 1
  • Michael R. Kanost
    • 1
  1. 1.Department of BiochemistryKansas State UniversityManhattan

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