New Major Histocompatibility Complex Class IIB Genes From Nurse Shark
The Major Histocompatibility Complex (MHC) codes for proteins that process and present antigens to T cells. The actual presenting proteins are the classical MHC molecules and they are subdivided into two classes, I and II. Each class of MHC protein has an antigen binding cleft (ABC) that is formed by two membrane distal domains and that binds processed peptides. Classical MHC proteins tend to be highly polymorphic with most variable sites clustered around the ABC. This polymorphism has an effect on the repertoire of peptides that can bind and on the T cell receptors (TCRs) selected in the thymus by each MHC molecule (1, 2). The polymorphism appears to be generated by point mutations and recombination events (3–8). Analyses of mammalian genes suggests that blocks of residues can be transferred between MHC alleles or loci by recombination. These blocks have been identified as hypervariable
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Major Histocompatibility Complex Gene Major Histocompatibility Complex Allele
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- 12.Bartl S. What sharks can tell us about the evolution of MHC genes. Immunol Rev 1998;166:317332.Google Scholar
- 13.Klein J. Natural History of the Major Histocompatibility Complex. New York:Wiley and Son; 1986.Google Scholar