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New Major Histocompatibility Complex Class IIB Genes From Nurse Shark

  • Simona Bartl
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 484)

Abstract

The Major Histocompatibility Complex (MHC) codes for proteins that process and present antigens to T cells. The actual presenting proteins are the classical MHC molecules and they are subdivided into two classes, I and II. Each class of MHC protein has an antigen binding cleft (ABC) that is formed by two membrane distal domains and that binds processed peptides. Classical MHC proteins tend to be highly polymorphic with most variable sites clustered around the ABC. This polymorphism has an effect on the repertoire of peptides that can bind and on the T cell receptors (TCRs) selected in the thymus by each MHC molecule (1, 2). The polymorphism appears to be generated by point mutations and recombination events (3–8). Analyses of mammalian genes suggests that blocks of residues can be transferred between MHC alleles or loci by recombination. These blocks have been identified as hypervariable

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Major Histocompatibility Complex Gene Major Histocompatibility Complex Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Simona Bartl
    • 1
  1. 1.Moss Landing Marine Laboratories

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