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Neurobehavioral Disturbances Associated with Disorders of the Pancreas

  • Chapter
Medical Neuropsychology

Part of the book series: Critical Issues in Neuropsychology ((CINP))

Abstract

As an organ devoted primarily to the digestion of food and the metabolism of carbohydrates, the pancreas appears to be a most unlikely source of neuropsy-chiatric disturbances. Yet an extensive clinical literature has reported significant mental status changes in individuals with several different pancreatic disorders. Severe depression and anxiety often are seen in patients with cancer of the pancreas long before any other somatic symptoms of their carcinoma are evident. Profound impairments affecting both emotional and intellectual domains have been reported in patients with pancreatitis, and severe inflammation of the pancreas is said to produce a“pancreatic encephalopathy.” Impairments on various cognitive measures also are seen in children and adults with diabetes mellitus, though these intellectual changes tend to be far less severe than those associated with pancreatitis, and they may be restricted to a relatively small subset of diabetic patients. In addition, mental confusion, slurred speech, motor incoordination, and a number of other symptoms of central nervous system (CNS) dysfunction typically are found in patients with hyperinsulinism secondary to islet cell tumors (insulinomas).

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  1. Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15213, USA

    Christopher M. Ryan

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    Ralph E. Tarter , Meryl A. Butters  & Sue R. Beers ,  & 

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Ryan, C.M. (2001). Neurobehavioral Disturbances Associated with Disorders of the Pancreas. In: Tarter, R.E., Butters, M.A., Beers, S.R. (eds) Medical Neuropsychology. Critical Issues in Neuropsychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1287-5_7

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