Development of a Neutron Energy-Biased in-Air Figure-of-Merit for Predicting in-Phantom BNCT Neutron Beam Characteristics
Maximizing the efficacy of a Boron Neutron Capture Therapy (BNCT) modality requires improvements in two areas: development of better boron-delivering drugs and better tailoring of the epithermal neutron beam. Previous attempts at the latter have not always been successful in predicting optimal in-phantom results, often assuming that all neutrons within a certain “useful” energy range are equally valuable for BNCT purposes. Some studies have recognized that higher energy epithermal neutrons (~10keV) and more forward-directed neutrons provide more penetrating beams. This results in higher tumor doses at centerline phantom depths. The exact effect of neutron beam energy spectrum shaping for BNCT has not been thoroughly explored. One reason for this has been the usage of inappropriate and often misleading in-air figures-of-merit.
KeywordsBoron Oncol Assure Reso Boronophenylalanine
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- 2.Coderre, J.A., Bergland, R., Capala, J., Chadha, M., Chanana, A.J., Elowitz, E., Joel, D.D., Liu, H.B., and Slatkin, D., “Boron Neutron Capture Therapy for Glioblastoma Multiforme using p-boronophenylalanine and Epithermal Neutrons-Trials Design and Early Clinical Results,” J. Neuro. Oncol. 33, 93–104 (1997).CrossRefGoogle Scholar
- 4.Chanana, A.D., “Boron Neutron-Capture Therapy of Glioblastoma Multiforme at the Brookhaven Medical Research Reactor, A Phase I/II Study, FDA IND 43,317, Protocol 4,” Med. Dep. Brookhaven Natl. Lab., Upton, NY 11973–5000, January, 1996.Google Scholar
- 5.Briesmeister, J.F., MCNP-A General Monte Carlo N-Particle Transport Code, Version 4B, Los Alamos National Lab, 1997.Google Scholar
- 6.Snyder, W.S., Fisher, Jr., H.L., Ford, M.R., and Warner, G.G., “Estimates for Absorbed Fractions for Monoenergetic Photon Sources Uniformly Distributed in Various Organs of a Heterogeneous Phantom (Appendix B),” J. Nucl. Medicine, MIRD Supplement No. 3, Pamphlet 5 (1969).Google Scholar
- 8.“Photon, Electron, Proton and Neutron Interaction Data for Body Tissues,” ICRU Report 46, February 28 (1992).Google Scholar