Advertisement

BNCT Microdosimetry of a Rat Glioma Model with BPA-F or BSH

  • W. S. KigerIII
  • H. Patel
  • R. G. Zamenhof

Abstract

The BNCT microdosimetry technique developed in the Harvard-MIT BNCT Program involves both experimental and computational components. First, a neutron-induced alpha particle track etch technique developed in our laboratory termed High Resolution Quantitative Autoradiography (HRQAR) is used to measure the microscopic distribution of 10B in a thin tissue section.1 HRQAR allows simultaneous visualization of tissue histology and track etch pits, which sample the 10B microdistribution. The polycarbonate track detector used in the technique is sensitive only to high LET particles (not protons) and has a linear response and sensitivity down to ~1 μg/g10B. By employing the actual boron microdistribution and tissue morphology obtained with the HRQAR technique in a 2D Monte Carlo simulation of charged particle transport and energy deposition in tissue, our approach to BNCT microdosimetry circumvents the simplifying assumptions usually required in microdosimetry, i.e., using elementary mathematical shapes and functions to represent the tissue architecture and boron distribution. This paper will discuss microdosimetric results obtained for 9L gliosarcoma in rats injected with boronophenylalanine-fructose (BPA-F) or Na2B12H11SH (BSH) using the HRQAR-based microdosimetry technique.

Keywords

Neutron Capture Boron Neutron Capture Therapy Heavy Charged Particle Track Etch ICRU Report 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    G.R. Solares, and R.G Zamenhof, A Novel Approach to the Microdosimetry of Neutron Capture Therapy, Part I: High-Resolution Quantitative Autoradiography Applied to Microdosimetry in Neutron Capture Therapy, Radiat. Res., 144:50–58, 1995.PubMedCrossRefGoogle Scholar
  2. 2.
    International Commission on Radiation Units and Measurements, “Photon, electron, proton, and neutron interaction data for body tissues,” ICRU Report 46, Bethesda, Md., U.S.A, 1992.Google Scholar
  3. 3.
    J.F. Ziegler, SRIM98, “The Stopping and Range of Ions In Matter,” IBM Research, Yorktown, NY (1998). http://www.research.ibm.com/ionbeams/SRIM/SRIMINTR.HTMGoogle Scholar
  4. 4.
    International Commission on Radiation Units and Measurements, “Microdosimetry,” ICRU Report 36, Bethesda, Md., U.S.A, 1983.Google Scholar
  5. 5.
    H.H. Rossi, and M. Zaider, “Microdosimetry and Its Applications,” Springer Verlag, New York, 1996.CrossRefGoogle Scholar
  6. 6.
    G. Solares, W.S. Kiger III, and R. Zamenhof, “Microdosimetry Studies at the Harvard/MIT Phase-I Clinical Trial of Boron Neutron Capture Therapy,” in Advances in Neutron Capture Therapy, edited by B. Larsson, J. Crawford, and R. Weinreich, Elsevier, Amsterdam (1997).Google Scholar
  7. 7.
    C.S. Yam, “Microdosimetric Studies for Neutron Capture Therapy and Techniques for Capture Element Selection,” Ph.D. Thesis, Massachusetts Institute of Technology, 1995.Google Scholar
  8. 8.
    C.S. Yam, G.R. Solares, and R.G. Zamenhof, Verification of the Two-Dimensional Approach for NCT Microdosimetry, Trans. Am. Nucl. Soc., 71:142, 1994.Google Scholar
  9. 9.
    T. Kageji, S. Nagahiro, K. Matsumoto, B. Otersen, D. Gabel, M. Nakaichi, and Y. Nakagawa, Subcellular biodistribution of Na2B12H11SH (BSH) in a rat glioma model, in “Frontiers in Neutron Capture Therapy,” M.F. Hawthorne, K. Shelly, R.W. Wiersema, eds., Kluwer Academic/Plenum Publishers, New York, 2001, pp. 927–931.CrossRefGoogle Scholar
  10. 10.
    S. Chandra, D.R. Lorey, D.R. Smith, and G.H. Morrison, In Vitro exposure of human T98G glioblas- toma cells to mixed BNCT drugs: acquiring independent quantitative images of boron atoms delivered by 10BPA-F and 11BSH in the same cell by SIMS ion microscopy, in “Frontiers in Neutron Capture Therapy,” M.F. Hawthorne, K. Shelly, R.W. Wiersema, eds., Kluwer Academic/Plenum Publishers, New York, 2001, pp. 905–909.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • W. S. KigerIII
    • 1
  • H. Patel
    • 2
  • R. G. Zamenhof
    • 3
  1. 1.Nuclear Reactor LaboratoryMassachusetts Institute of TechnologyUSA
  2. 2.Research Institute, Churchill HospitalUniversity of OxfordEngland
  3. 3.Department of Radiology, Beth Israel Deaconess Medical CenterHarvard Medical SchoolUSA

Personalised recommendations