Abstract
Clinical trials of BNCT for glioblastoma have been underway around the World. In Japan, the new reactor JRR-4 has been now reconstructed especially for therapeutic irradiation. From the clinical point of view, pathological studies are very important in understanding post BNCT clinical and MRI findings. However, pathological findings on target lesions, which received BNCT have scarcely been reported.1 We report an interesting and rare autopsy case of giant cell glioblastoma and compare MRI findings with autopsy findings, and discuss histopathlogical changes after BNCT
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A.K. Asbury, R.G. Ojemann, S.L. Nielsen, and W.H. Sweet, Neuropathologic study of fourteen cases if malignant brain tumor treated by boron-10 slow neutron capture radiation, J. Neuropathol. Exp. Neurol., 31(2), pp. 278–303, 1972.
K. Kitamura, Y. Nakagawa, T. Minobe, T. Masuda, and T. Kageji, Radiation necrosis and related factors after boron neutron capture therapy, in: Advances in Neutron Capture Therapy Vol. II Chemistry and Biology, Larsson, Crawford and Weinreich ed., Elsevier, Amsterdam, pp. 679–682, 1997.
H. Kawano, T. Kubota, K. Sato, T. Goya, S. Arikawa, and S. Wakisaka, Immunohistochemical study of giant cell in glioblastoma, Clin Neuropathol., 14: pp. 118–123, 1995.
A. Peraud, K. Watanabe, K.H. Plate, Y. Yonekawa, P. Kleihues, and H. Ohgaki, p53 mutations versus EGF receptor Expression in Giant Cell Glioblastomas, J. Neuropath. Exp. Neurol., 56: pp. 1236–1241, 1997.
C. Vroegindeweij, F.J. Wheeler, F. Stecher-Rasmussen, R. Huiskamp, and D. Gabel, A Microdosimetry model for BNCT analysis, in: “Cancer Neutron Capture Therapy”, Mishima Y ed., Plenum Press, New York, pp. 485–493, 1996.
R.A. Rydin, O.L. Deutsch, and B.B. Murray, The effect of geometry on capillary wall dose for boron neutron capture therapy, Phys. Med. Biol., 21: pp. 134–138, 1976.
G.M. Morris, J.A. Coderre, A. Bywaters, E. Whitehouse, and J.W. Hopewell, Boron neutron capture irradiation of the rat spinal cord: Histopathological Evidence of a vascular-mediated pathogenesis, Radiation Research, 146:313–320, 1996.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Nakai, K. et al. (2001). An Autopsy Report of a Glioblastoma Case after Boron Neutron Capture Therapy. In: Hawthorne, M.F., Shelly, K., Wiersema, R.J. (eds) Frontiers in Neutron Capture Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1285-1_15
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1285-1_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5478-9
Online ISBN: 978-1-4615-1285-1
eBook Packages: Springer Book Archive