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A Combination of Immunohistochemistry and Photoelectron Spectromicroscopy for Investigations of Subcellular Boron Distribution

  • Michael Neumann
  • Gelsomina De Stasio
  • Benjamin Gilbert
  • José Redondo
  • Detlef Gabel

Abstract

We have combined immunohistochemistry and photoelectron spectromicroscopy with synchrotron radiation for investigations of the subcellular distribution and the chemical state of boron in human glioma tissue.

Keywords

Synchrotron Radiation Chemical State Subcellular Distribution Boron Neutron Capture Therapy Boron Oxide 
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References

  1. 1.
    De Stasio, G., Pochon, S., Lorusso, G.F., Tonner, B.P., Mercanti, D., Ciotti, M.T., Oddo, N., Galli, P., Perfetti, P., and Margaritondo, G.: Zinc uptake by brain cells: “surface” versus “bulk”, J. Phys. D: Applied Physics 29:2209–2215, 1996.CrossRefGoogle Scholar
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    Otersen, B., Haritz, D., Grochulla, F., Bergmann, M., Sierralta, W.D., and Gabel, D.: Binding and distribution of Na2B12H11SH on cellular and subcellular level in tumor tissue of glioma patients in boron neutron capture therapy; J. Neuro-Oncol. 33:131–139, 1997.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Michael Neumann
    • 1
  • Gelsomina De Stasio
    • 2
    • 3
  • Benjamin Gilbert
    • 2
  • José Redondo
    • 2
  • Detlef Gabel
    • 1
  1. 1.Department of ChemistryUniversity of BremenGermany
  2. 2.Institut de Physique AppliqueéEcole Polytechnique Fédérale de LausanneSwitzerland
  3. 3.Instituto di Struttura della Materia del Consiglio Nazionale delleRicercheItaly

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