A Potential New BNCT Agent
Boron neutron capture therapy (BNCT) is a binary approach to cancer therapy.1 In this protocol, boron-10 is delivered to the tumor tissue, and upon irradiation with thermal neutrons, cytotoxic α-particles and high energy lithium-7 ions are produced. The linear energy transfer (LET) of these heavy charged particles (which is on the order of one cell diameter) makes them lethal to the boron-containing cells. The success of this protocol is dependent upon the selective delivery of a sufficient quantity of boron-10 to the tumor tissues (10–30μg boron-10/g of tumor with tumor to normal tissue ratio of 3:1). While various carrier molecules are under investigation as potential boron-delivery agents, the only drug currently in clinical trials in the United States is a boron-containing amino acid,2 4-dihydroxyborylphenylalanine (BPA).
KeywordsEthyl Cage Boron Ketone Cyanide
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