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BNCEFN Optimisation with Lead Blocks Collimation and Graphite Embedding

The Monte Carlo Simulation of Various Fast Neutron Beams Intercomparison
  • Jean-Philippe Pignol
  • Philippe Paquis
  • Roland Sabattier
  • Arlene Lennox
  • Thomas Kroc
  • Dan Jones
  • Jakobus Slabbert
  • Cheikh M. B. Diop
  • Gilbert Blondiau
  • Noël Breteau

Abstract

Several authors have demonstrated the feasibility and efficiency of Boron Neutron Capture Enhancement of Fast Neutron (BNCEFN) at their facility.1, 2, 3, 4, 5 The two major difficulties of this technique are to incorporate a large amount of 10B selectively into the tumor (>100µg/g) and to optimize neutron thermalization in the tissues. Unfortunately, it has been also demonstrated that the number of thermal neutrons per fast neutron Gy (nth.Gy−1) is inversely proportional to fast neutron energy, and strongly proportional to the size of fast neutron irradiation field.3, 4, 5 Thus, a dramatic decrease of thermal neutron flux is seen when the irradiation fields are reduced to conform the target volume.

Keywords

Thermal Neutron Fast Neutron Boron Neutron Capture Therapy Thermal Neutron Flux Full Optimization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Jean-Philippe Pignol
    • 1
  • Philippe Paquis
    • 2
  • Roland Sabattier
    • 3
  • Arlene Lennox
    • 4
  • Thomas Kroc
    • 4
  • Dan Jones
    • 5
  • Jakobus Slabbert
    • 5
  • Cheikh M. B. Diop
    • 6
  • Gilbert Blondiau
    • 3
  • Noël Breteau
    • 3
  1. 1.Département de radiothérapieInstitut Gustave-RoussyVillejuif cedexFrance
  2. 2.Service de NeurochirurgieHôpital PasteurNice cedex 1France
  3. 3.CERI-CNRSOrléans Cedex 2France
  4. 4.Fermi National Accelerator LaboratoryBataviaUSA
  5. 5.National Accelerator CentreZA FaureSouth Africa
  6. 6.Commissariat à l’Energie AtomiqueSERMAGif sur Yvette cedexFrance

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