BNCEFN Optimisation with Lead Blocks Collimation and Graphite Embedding
Several authors have demonstrated the feasibility and efficiency of Boron Neutron Capture Enhancement of Fast Neutron (BNCEFN) at their facility.1, 2, 3, 4, 5 The two major difficulties of this technique are to incorporate a large amount of 10B selectively into the tumor (>100µg/g) and to optimize neutron thermalization in the tissues. Unfortunately, it has been also demonstrated that the number of thermal neutrons per fast neutron Gy (nth.Gy−1) is inversely proportional to fast neutron energy, and strongly proportional to the size of fast neutron irradiation field.3, 4, 5 Thus, a dramatic decrease of thermal neutron flux is seen when the irradiation fields are reduced to conform the target volume.
KeywordsThermal Neutron Fast Neutron Boron Neutron Capture Therapy Thermal Neutron Flux Full Optimization
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