Abstract
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor of the basic helix-loop-helix family) It binds and is activated by a number of compounds, including polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene (B[a]P), which are generated during the combustion of fossil fuels and are present in tobacco smoke and smoked meats. The AHR also binds halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), which is a contaminant formed during the manufacture of chlorophenols (for chemical structures see Fig. 1). Both these classes of AHR ligands are persistent environmental pollutants and cause a variety of toxic and carcinogenic effects that are mediated by the AHR.
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References
Rowlands, J.C., and Gustafsson, J.A. Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol., 27: 109–134, 1997.
Whitlock, J. P. Jr, Chichester, C. H., Bedgood, R. M., Okino, S. T., Ko, H. P., Ma, Q., Dong, L., Li, H., and Clarke-Katzenberg, R. Induction of drug-metabolizing enzymes by dioxin. Drug Metab. Rev., 29: 1107–1127, 1997.
Peltonen, K., and Dipple, A. Polycyclic aromatic hydrocarbons: chemistry of DNA adduct formation. J. Occup. Environ. Med., 37: 52–58, 1995.
Block, G., Patterson, B., and Subar, A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer, 18: 1–29, 1992.
Steinmetz, K. A., and Potter, J. D. Vegetables, fruit, and cancer prevention: a review. J. Am. Diet Assoc., 96: 1027–1039, 1996.
Ciolino H.P., Wang T.T., and Yeh G.C. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Cancer Res., 58: 2754–2760, 1998.
Ciolino H.P., Daschner P.J., Wang T.T., and Yeh G.C. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 IA in MCF-7 human breast carcinoma cells. Biochem. Pharmacol., 56: 197–206, 1998.
Ciolino H.P., and Yeh G.C. The flavonoid galangin is an inhibitor of CYPIA1 activity and an agonisdantagonist of the aryl hydrocarbon receptor. Br. J. Cancer, 79: 1340–1346, 1999.
Ciolino H.P., Daschner P.J., and Yeh G.C. Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP I Al transcription differentially. Biochem. J., 40: 715–722, 1999.
Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghom, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275: 218–220, 1997.
Ciolino H.P., Daschner P.J., and Yeh G.C. Resveratrol inhibits transcription of CYPIA1 in vitro by preventing activation of the aryl hydrocarbon receptor. Cancer Res., 58: 5707–5712, 1998.
Ciolino H.P and Yeh G.O Inhibition of aryl hydrocarbon-induced cytochrome P-450 lA1 enzyme activity and CYPIAI expression by resveratrol. Mol. Pharmacol., 56: 760–767,1999
Santostefano, M., Merchant, M., Arellano, L., Morrison, V., Denison, M.S., and Safe, S. (a)-Naphthoflavone-induced CYP1A1 gene expression and cytosolic aryl hydrocarbon receptor transformation. Mol. Pharmacol., 43: 200–206, 1993.
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Ciolino, H.P., Yeh, G.C. (2001). The Effects of Resveratrol on CYP1A1 Expression and Aryl Hydrocarbon Receptor Function In Vitro . In: Nutrition and Cancer Prevention. Advances in Experimental Medicine and Biology, vol 492. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1283-7_14
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DOI: https://doi.org/10.1007/978-1-4615-1283-7_14
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