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The Transfusion-Transmitted Viruses in Blood Transfusion

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Hemophilia Care in the New Millennium

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 489))

Abstract

Over the past 15 years, issues concerning the safety of the blood supply have caused significant changes in both national blood policies and the methods used in blood collection and screening in the United States. More specifically, the discovery that Human Immunodeficiency Virus (HIV) could be transmitted by blood transfusion heightened public awareness and concern. Multiple layers of protection now exist to reduce the risk of transmission of infectious agents through the transfusion of blood and blood components’. First, the donor pool is entirely voluntary, eliminating those persons donating for monetary gain. Second, extensive donor education and history-based screening procedures have been implemented. Third, extensive laboratory testing is performed on each donation. Finally, call back procedures and confidential unit exclusion provide mechanisms for donors who donated under peer pressure and believe they may provide a risk to transfusion recipients to indicate that their blood may not be suitable for transfusion. These multiple tiers of screening and testing have made the blood supply the safest it has ever been. The major threats that remain are in the donation of blood by seronegative donors during an infectious window period prior to detectable seroconversion and/or in the transmission of a virus or agent unrecognized as pathogenic and for which no test or process exists to eliminate it.

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Author information

Authors and Affiliations

  1. National Medical Center 111 Michigan Ave NW, Department of Transfusion Medicine Oncology Childrens Hospital, Washington, DC, 20010

    Naomi L. C. Luban M.D.

  2. Oncology Childrens Hospital, National Medical Center, Department of Hematology, 111 Michigan Ave NW, Washington, DC, 20010

    Rima F. Jubran M.D.

Authors
  1. Naomi L. C. Luban M.D.
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  2. Rima F. Jubran M.D.
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Editor information

Editors and Affiliations

  1. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Dougald M. Monroe

  2. Novo Nordisk A/S, MĂĄlov, Denmark

    Ulla Hedner

  3. University of Lund, Lund, Sweden

    Ulla Hedner

  4. Duke University and Durham VA Medical Centers, Durham, North Carolina, USA

    Maureane R. Hoffman

  5. HĂ´pital Edouard Herriot, Lyon, France

    Claude Negrier

  6. Guys’ and St. Thomas’s Trust, London, UK

    Geoffrey F. Savidge

  7. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Gilbert C. White II

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© 2001 Springer Science+Business Media New York

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Luban, N.L.C., Jubran, R.F. (2001). The Transfusion-Transmitted Viruses in Blood Transfusion. In: Monroe, D.M., Hedner, U., Hoffman, M.R., Negrier, C., Savidge, G.F., White, G.C. (eds) Hemophilia Care in the New Millennium. Advances in Experimental Medicine and Biology, vol 489. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1277-6_1

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  • DOI: https://doi.org/10.1007/978-1-4615-1277-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5474-1

  • Online ISBN: 978-1-4615-1277-6

  • eBook Packages: Springer Book Archive

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