Abstract
Indoleamine-related ß-carbolines are proposed as natural MPTP-like toxicants or protoxicants. An enzyme in mammalian brain methylates ß-carbolines, sequentially forming 2-mono-[N]-methylated and 2,9-di-[N,N’]-methylated ß-carbolinium cations. These N-methylated ß-carbolinium cations are structural analogs of MPP+ with a nitrogen bridge. Because of their similar neurotoxicity to MPP+, they could be underlying factors in idiopathic Parkinson’s disease.
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Matsubara, K. (2000). N-Methyl-ß-Carbolinium Neurotoxins in Parkinson’s Disease. In: Storch, A., Collins, M.A. (eds) Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1269-1_14
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DOI: https://doi.org/10.1007/978-1-4615-1269-1_14
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