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T-Independent IgA Responses to Microbial Polysaccharides

  • Chapter
The Molecular Immunology of Complex Carbohydrates —2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 491))

Abstract

There is accumulating evidence indicating the presence in vivo of T -independent routes of IgA response in addition to the conventional T-dependent IgA response. Factors influencing these alternative pathways of IgA responses may include the structural characteristics of a stimulating antigen, the nature of responding B cells, and the microenvironment. The structural complexity of polysaccharide antigens has made it difficult to summarize a general scheme for the antibody responses they induce. Instead, one may expect that each individual polysaccharide may be able to create a unique microenvironment by activation of specific cell populations in the repertoires of non-T cell types. A specific pattern of B cell response may thus be elicited by TI stimulation. Recognition of such a unique property of a TI antigens is necessary for us to better understand the T -independent IgA response. Information obtained may have an impact on the development of vaccination strategies directed at the mucosal immunity mediated by IgA antibodies.

Article FootNote

We are grateful to Professor Elvin A. Kabat for his long-term support of this project and to Ms Emily Chenette for proof-reading of this manuscript. This work is supported by NIH grant AI45326 to D.W.

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  1. Immunology Laboratory, Columbia Genome Center, College of Physicians & Surgeons, Columbia University, New York, NY, 10032, USA

    Denong Wang

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  1. Glyco Research Laboratory Institutes of Basic Medical Sciences and Natural Products, College of Medicine Chang-Gung University, Kwei-san, Tay-yuan, Taiwan

    Albert M. Wu

  2. Tao-yuan, 333, Taiwan

    Albert M. Wu

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Wang, D. (2001). T-Independent IgA Responses to Microbial Polysaccharides. In: Wu, A.M. (eds) The Molecular Immunology of Complex Carbohydrates —2. Advances in Experimental Medicine and Biology, vol 491. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1267-7_32

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  • DOI: https://doi.org/10.1007/978-1-4615-1267-7_32

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