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Red Blood Cell Antigens Responsible for Inherited Types of Polyagglutination

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The Molecular Immunology of Complex Carbohydrates —2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 491))

Abstract

The three described types on inheritable polyagglutination are related to altered carbohydrate structures in glycoproteins or/and glycolipds on the erythrocyte surface. HEMPAS, a condition causing anemia and other patholoGlcal symptoms, is characterized by impaired biosynthesis of N-glycans, mostly those carried by band 3 and band 4.5 erythrocyte membrane proteins. Cad erythrocytes have abnormal glycophorin O-glycans, structurally related to the more common human Sdaand murine CT determinants, and accumulate an Sda-like ganglioside. NOR erythrocytes express recently detected abnormal α -galactose-terminated glycosphingolipids, which strongly react with G. simplicifolia IB4 isolectin, but do not react with human anti-Galαl-3Gal antibodies.

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  1. Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, 53-114, Poland

    Elwira Lisowska & Maria Duk

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  1. Elwira Lisowska
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  1. Glyco Research Laboratory Institutes of Basic Medical Sciences and Natural Products, College of Medicine Chang-Gung University, Kwei-san, Tay-yuan, Taiwan

    Albert M. Wu

  2. Tao-yuan, 333, Taiwan

    Albert M. Wu

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Lisowska, E., Duk, M. (2001). Red Blood Cell Antigens Responsible for Inherited Types of Polyagglutination. In: Wu, A.M. (eds) The Molecular Immunology of Complex Carbohydrates —2. Advances in Experimental Medicine and Biology, vol 491. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1267-7_11

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