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Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis

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Neuropathology and Genetics of Dementia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 487))

Abstract

The same proteins accumulate in the brains of patients with sporadic or hereditary Alzheimer’s disease and in the muscle fibres of patients with sporadic inclusion-body myositis (s-IBM) and hereditary inclusion-body myopathy (h-IBM). The pathogenic mechanisms underlying both disorders may be similar. Therefore, IBM may serve as an easily accessible peripheral model for the aetiology of Alzheimer’s disease1.

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Authors and Affiliations

  1. Department of Neurology, Technical University of Dresden, Dresden, Germany

    Johannes B. Lampe & Heinz Reichmann

  2. Friedrich Baur Institute Munich, Munich, Germany

    Maggie C. Walter

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  1. Johannes B. Lampe
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  2. Maggie C. Walter
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  1. University of Basel, Basel, Switzerland

    Markus Tolnay  & Alphonse Probst  & 

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Lampe, J.B., Walter, M.C., Reichmann, H. (2001). Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis. In: Tolnay, M., Probst, A. (eds) Neuropathology and Genetics of Dementia. Advances in Experimental Medicine and Biology, vol 487. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1249-3_18

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  • DOI: https://doi.org/10.1007/978-1-4615-1249-3_18

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