Abstract
Current therapy for autoimmune disease is based on broad-spectrum immune suppression, rather than specific correction of defective tolerance mechanisms. On the preventive front, we are not yet able to identify individuals at risk of autoimmune disease or predict clinical course. To develop more specific therapeutic and diagnostic tools, we will need a map of the cellular and molecular pathways and genes that underpin immunological self-tolerance, illuminating the points where the process goes wrong and where it can be corrected.
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Goodnow, C.C. et al. (2001). Autoimmunity, Self-Tolerance and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways. In: Gupta, S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VIII. Advances in Experimental Medicine and Biology, vol 490. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1243-1_4
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DOI: https://doi.org/10.1007/978-1-4615-1243-1_4
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