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Factors Contributing to Autoimmune Disease

  • Chapter
Book cover Mechanisms of Lymphocyte Activation and Immune Regulation VIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 490))

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Abstract

T cells that emigrate from the thymus with specificities towards self-antigens face one of two fates. They either remain in the peripheral repertoire if they are immunologically unaware or ignorant of their cognate ligand., or if they encounter sufficient concentrations of their cognate ligand, the self-reactive T cells are subject to peripheral tolerance. Pathological autoimmunity can arise when either or both of these mechanisms are breached.

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Authors and Affiliations

  1. Departments of Medical Biophysics and Immunology, Ontario Cancer Institute, 610 University Ave., M5G 2M9, Toronto, ON, Canada

    Kristine M. Garza, Linh T. Nguyen, Russell G. Jones & Pamela S. Ohashi

Authors
  1. Kristine M. Garza
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  2. Linh T. Nguyen
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  3. Russell G. Jones
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  4. Pamela S. Ohashi
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Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

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Garza, K.M., Nguyen, L.T., Jones, R.G., Ohashi, P.S. (2001). Factors Contributing to Autoimmune Disease. In: Gupta, S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VIII. Advances in Experimental Medicine and Biology, vol 490. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1243-1_2

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  • DOI: https://doi.org/10.1007/978-1-4615-1243-1_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5458-1

  • Online ISBN: 978-1-4615-1243-1

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