Factors Contributing to Autoimmune Disease

  • Kristine M. Garza
  • Linh T. Nguyen
  • Russell G. Jones
  • Pamela S. Ohashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 490)


T cells that emigrate from the thymus with specificities towards self-antigens face one of two fates. They either remain in the peripheral repertoire if they are immunologically unaware or ignorant of their cognate ligand., or if they encounter sufficient concentrations of their cognate ligand, the self-reactive T cells are subject to peripheral tolerance. Pathological autoimmunity can arise when either or both of these mechanisms are breached.


Cell Tolerance Cell Deletion Antigen Present Cell Activation Survival Molecule Cell Receptor Transgenic Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Kristine M. Garza
    • 1
  • Linh T. Nguyen
    • 1
  • Russell G. Jones
    • 1
  • Pamela S. Ohashi
    • 1
  1. 1.Departments of Medical Biophysics and ImmunologyOntario Cancer InstituteTorontoCanada

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