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Cytokine Blockade in Rheumatoid Arthritis

  • Marc Feldmann
  • Ravinder N. Maini
  • Jan Bondeson
  • Peter Taylor
  • Brian M. J. Foxwell
  • Fionula M. Brennan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 490)

Abstract

As we enter the 2000’s it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFa therapy, the current status of therapy and focus on the regulation of TNFa production in rheumatoid synovium. New approaches to studying TNF regulation in RA and of elucidating the controversial role of T cells in this complex disease will be described.

Keywords

Rheumatoid Arthritis Tumor Necrosis Factor Receptor TNFa Production Rheumatoid Synovium Tumour Necrosis Factor mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Marc Feldmann
    • 1
  • Ravinder N. Maini
    • 1
  • Jan Bondeson
    • 1
  • Peter Taylor
    • 1
  • Brian M. J. Foxwell
    • 1
  • Fionula M. Brennan
    • 1
  1. 1.Kennedy Institute of RheumatologyHammersmith, LondonUK

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