Multiple Sclerosis and Gene Expression Profiling
In gene microarray studies on MS brain, my lab has been studying mRNA from active MS brain lesions from MS brains, and comparing them to three control brains, as well as four brains with Huntington’s Disease, and four brains with Parkinson’s Disease.1, 2 Using a 6800 gene Affymetrix microarray, large increases in transcription of genes encoding key components of the immune response have been seen.1, 2, 3
KeywordsMultiple Sclerosis Demyelinating Disease Altered Peptide Ligand Myelin Antigen Nitric Oxide Metabolite
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- 1.Lock C, Steinman L, Oksenberg J, Raine C, and Heller R. Large-scale expression analysis of MS lesions using gene microarrays. Neurology 52, A439, (1999).Google Scholar
- 2.Karpuj MV and Steinman L. Transcriptional profile of Huntington disease brain with gene microarrays. Society for Neuroscience Abstracts 25, part I, 541, (1999).Google Scholar