Multiple Sclerosis and Gene Expression Profiling

  • Lawrence Steinman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 490)


In gene microarray studies on MS brain, my lab has been studying mRNA from active MS brain lesions from MS brains, and comparing them to three control brains, as well as four brains with Huntington’s Disease, and four brains with Parkinson’s Disease.1, 2 Using a 6800 gene Affymetrix microarray, large increases in transcription of genes encoding key components of the immune response have been seen.1, 2, 3


Multiple Sclerosis Demyelinating Disease Altered Peptide Ligand Myelin Antigen Nitric Oxide Metabolite 
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  1. 1.
    Lock C, Steinman L, Oksenberg J, Raine C, and Heller R. Large-scale expression analysis of MS lesions using gene microarrays. Neurology 52, A439, (1999).Google Scholar
  2. 2.
    Karpuj MV and Steinman L. Transcriptional profile of Huntington disease brain with gene microarrays. Society for Neuroscience Abstracts 25, part I, 541, (1999).Google Scholar
  3. 3.
    Lock C, Oksenberg J and Steinman L. The role of TNFa and lymphotoxin in demyelinating disease. Ann Rhem Dis 58, 1121–1128, (1999).CrossRefGoogle Scholar
  4. 4.
    Steinman L Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system. Cell 85, 299–302, (1996)PubMedCrossRefGoogle Scholar
  5. 5.
    Steinman L. Assessment of the utility of animal models for multiple sclerosis and demyelinating disease in the design of rational therapy. Neuron, 24, 511–514, (1999).PubMedCrossRefGoogle Scholar
  6. 6.
    Heller, R. A. et al. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA 94, 2150–2155 (1997).PubMedCrossRefGoogle Scholar
  7. 7.
    Steinman L. Multiple mechanisms of multiple sclerosis. Nature Med 6,15–16, (2000).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Lawrence Steinman
    • 1
  1. 1.Dept. of Neurological SciencesStanford UniversityStanfordUSA

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