Multiple Sclerosis and Gene Expression Profiling

Abstract

In gene microarray studies on MS brain, my lab has been studying mRNA from active MS brain lesions from MS brains, and comparing them to three control brains, as well as four brains with Huntington’s Disease, and four brains with Parkinson’s Disease.^{1, 2} Using a 6800 gene Affymetrix microarray, large increases in transcription of genes encoding key components of the immune response have been seen.^{1, 2, 3}