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Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models

  • Kui Liu
  • Edward K. Wakeland
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 490)

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the production of autoantibodies to a spectrum of nuclear antigens, and the development of inflammatory Processes potentially affecting multiple organ systems with varied clinical manifestations. Although the etiology of SLE is still unclear, it has been established that genetic factors play an important role in determining disease susceptibility.

Keywords

Systemic Lupus Erythematosus Lupus Nephritis Epistatic Interaction Congenic Strain Varied Clinical Manifestation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Kui Liu
    • 1
  • Edward K. Wakeland
    • 1
  1. 1.Center for ImmunologyThe University of Texas Southwestern Medical Center at DallasDallasUSA

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