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Dysregulation of AQP2 in Bilateral and Unilateral Ureteral Obstruction

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Molecular Biology and Physiology of Water and Solute Transport
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Abstract

Urinary tract obstruction is a complex disease which results in profound changes in renal hemodynamics and tubule function ultimately resulting in an impaired urinary concentrating capacity.

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References

  • Blackshear JL Spielman WS Knox FG Romero JC 1979 Dissociation of renin release and renal vasodilation by prostaglandin synthesis inhibitors Am J Physiol 237: F20–24

    Google Scholar 

  • Deen PMT Verdijk MAJ Knoers NVAM Wierenga B Monnens LAH Van Os CH Van Oost BA 1994 Requirement of human renal water channel aquaporin-2 for vasopressin- dependent concentration of urine Science 264: 92–95

    Article  PubMed  CAS  Google Scholar 

  • Frokiaer J Marples D Knepper MA Nielsen S 1996 Bilateral ureteral obstruction downregulates expression of vasopressin- sensitive AQP-2 water channel in rat kidney Am J Physiol 270: F657–F668

    Google Scholar 

  • Frøkiær J Marples D Mønster B Nielsen UB Knepper MA Nielsen S 1997 Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral obstruction of the ureter Am J Physiol 273: F213–223

    Google Scholar 

  • Fushimi K Uchida S Hara Y Hirata Y Marumo F Sasaki S 1993 Cloning and expression of apical membrane water channel of rat kidney collecting tubule Nature 361: 549–552

    Article  PubMed  CAS  Google Scholar 

  • Harris RH Gill JM 1981 Changes in glomerular filtration rate during complete ureteral obstruction in rats Kidney lnt 19: 603–608

    Article  CAS  Google Scholar 

  • Kuwahara M Fushimi K Terada Y Bai L Marumo F Sasaki S 1995 cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes J Biol Chem 270: 10384–10387

    Article  PubMed  CAS  Google Scholar 

  • Nielsen S Chou C-L Marples D Christensen El Kishore BK Knepper MA 1995 Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane Proc Natl Acad Sci USA 92: 1013– 1017

    Article  PubMed  CAS  Google Scholar 

  • Nielsen S DiGiovanni SR Christensen El Knepper MA Harris HW 1993 Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney Proc Natl Acad Sci USA 90: 11663–11667

    Article  PubMed  CAS  Google Scholar 

  • Provoost AP Molenaar JC 1981 Renal function during and after a temporary complete unilateral ureter obstruction in rats Invest Urol 18: 242–46

    PubMed  CAS  Google Scholar 

  • Sabolic I Katsura T Verbavatz JM Brown D 1995 The AQP2 water channel: effect of vasopressin treatment microtubule disruption and distribution in neonatal rats (published erratum appears in J Membr Biol 1995 May; 145(1): 107-8) J Membr Biol 143: 165–175

    Article  PubMed  CAS  Google Scholar 

  • Saulo Klahr 1997 Obstructive Nephropathy: Pathophysiology and Management In: Robert WSchrier (ed) Renal and Electrolyte Disorders vol 1 558–559

    Google Scholar 

  • Wilson DR 1980 Pathophysiology of obstructive nephropathy Kidney Int 18: 281–292

    Article  PubMed  CAS  Google Scholar 

  • Wright FS 1982 Effects of urinary tract obstruction on glomerular filtration rate and renal blood flow Sem Nephrol 2:5–16

    Google Scholar 

  • Yamamoto T Sasaki S Fushimi K Ishibashi K Yaoita E Kawasaki K Marumo F Kihara 11995 Vasopressin increases AQP-CD water channel in apical membrane of collecting duct cells in Brattleboro rats Am J Physiol 268: C1546–C1551

    Google Scholar 

  • Yarger WE 1991 Urinary Tract Obstruction In: Brenner BM Rector FC (eds) The Kidney vol 2 4 ed Philadelphia: Saunder; 1768–1808

    Google Scholar 

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© 2000 Springer Science+Business Media New York

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Li, C., Wang, W., Nielsen, S., FrØkiær, J. (2000). Dysregulation of AQP2 in Bilateral and Unilateral Ureteral Obstruction. In: Hohmann, S., Nielsen, S. (eds) Molecular Biology and Physiology of Water and Solute Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1203-5_31

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  • DOI: https://doi.org/10.1007/978-1-4615-1203-5_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5439-0

  • Online ISBN: 978-1-4615-1203-5

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