Urinary Excretion of Aquaporin-2 Water Channel is Dominant in Pathological State of Arginine Vasopressin-Induced Impaired Water Excretion

  • Sane Ishikawa
  • Takako Saito
  • Akinori Fukagawa
  • Tomoatsu Nakamura
  • Ikuyo Kusaka
  • Minori Higashiyama
  • Shoichiro Nagasaka
  • Toshikazu Saito

Abstract

There is impaired water excretion in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH), congestive heart failure, liver cirrhosis with ascites and adrenal insufficiency (Bartter and Schwartz 1967, Bichet et al., 1982, Schrier 1988a, b). In these clinical settings there is hyponatremia to a various extent. Non-suppressible release of arginine vasopressin (AVP) is found despite hypoosmolality, which should suppress plasma AVP to undetectable levels (Bartter and Schwartz 1967, Bichet et al., 1982, Schrier 1988a, b, Ishikawa et al., 1982, Ishikawa 1986).

Keywords

Creatinine Arginine Glucocorticoid Vasopressin Mineralocorticoid 

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Sane Ishikawa
    • 1
  • Takako Saito
    • 1
  • Akinori Fukagawa
    • 1
  • Tomoatsu Nakamura
    • 1
  • Ikuyo Kusaka
    • 1
  • Minori Higashiyama
    • 1
  • Shoichiro Nagasaka
    • 1
  • Toshikazu Saito
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of MedicineJichi Medical SchoolTochigiJapan

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