Abstract
The sympathetic or parasympathetic nerves innervate the salivary glands. In general, parasympathetic stimulation produces the high flow of saliva as a result of the activation of M3 muscarinic receptors on the salivary gland cells. In contrast, noradrenaline released from sympathetic nerve endings acts at both β- and α-adrenergic receptors in the salivary glands. Activation of b-adrenoceptors induces the secretion by exocytosis of salivary proteins contained in zymogen granules, whereas activation of al-adrenoceptors induces the fluid secretion (Baum 1993, Turner 1993).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baum BJ 1993 Principles of saliva secretion Ann NY Acad Sci 694: 1723
He X Tse CM Donowitz M Alper SL Gabriel SE and Baum BJ1997 Polarized distribution of key membrane transport proteins in rat submandibular gland Pflugers Arch-Eur J Physiol 433: 260268
Ishikawa Y Eguchi T Skowronski MT and Ishida H 1998 Acetylcholine acts on M3 muscarinic receptors and induces the translocation of aquaporin5 water channel via cytosolic Ca2+elevation in rat parotid glands Biochem Biophys Res Commun 245: 835840
Ishikawa Y Skowronski MT Inoue N and Ishida H 1999 al-Adrenoceptor-induced trafficking of aquaporin-5 to the apical plasma membrane of rat parotid cells Biochem Biophys Res Commun 265: 94100
Koyama Y Yamamoto T Kondo D Funaki H Yaoita E Kawasaki K Sato N Hatakeyama K and Kihara I 1997 Molecular cloning of a new aquaporin from rat pancreas J Biol Chem 272: 3032930333
Ma T and Verkman AS 1999 Aquaporin water channels in gastrointestinal physiology J Physiol 517: 317326
Ma T Song Y Gillespie A Carlson EJ Epstein CJ and Verkman AS 1999 Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channelsJ Biol Chem 274: 2007120074
Matsuzaki T Suzuki T Koyama H Tanaka S and Takata K 1999 Aquaporin-5 (AQP5) a water channel protein in the rat salivary and lacrimal glands: immunolocalization and effect of secretory stimulation Cell Tissue Res 295: 513521
Raina S Preston GM Guggino WB and Agre P 1995 Molecular cloning and characterization of an aquaporin cDNA from salivary lacrimal and respiratory tissues J Biol Chem 270: 19081912
Turner BJ 1993 Mechanisms of fluid secretion Ann NY Acad Sci 694: 24- 35
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ishikawa, Y., Ishida, H. (2000). Neurotransmitters Regulate the Amount of AQP5 in the Apical Plasma Membrane Via [Ca2+]i in Parotid Acinar Cells. In: Hohmann, S., Nielsen, S. (eds) Molecular Biology and Physiology of Water and Solute Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1203-5_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1203-5_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5439-0
Online ISBN: 978-1-4615-1203-5
eBook Packages: Springer Book Archive